As a consequence of remote site and the characteristics of the regional structure of East Macedonia and Thrace in NE-Greece the perspectives of development of this peripheral region seem to be bad. They are lying -that is the opinion of the author, based on long term research work in that region and especially a research work which was sponsored by the Volkswagen foundation- in a combination of small scale agriculture, an industry which based on agriculture and other natural ressources of the region and tourism which doesn't destroy the basis of the development. As a basis the manifold nature with is plenty of threatened species of plants and animals and its architectural testimonies of a long history is concerned. If it is accepted, it demandes a policy of regional development which differs from the actual. How a concept like this for East Macedonia and Thrace with its special ethnical structure is transferable to other peripheral regions in the EC with similar characteristics has to be proved.