The morphofunctional changes characteristics in the brain tissue at multiple mild brain injury were studied in the experiment. A marked diffuse lesion of all brain sections was observed in a case of repeated multiple mild brain injury, with the injured hemisphere affected to the greatest extent, which manifested in disturbed intracerebral blood circulation, dystrophic-destructive changes in most neurons without any signs of a marked intracellular reparative regeneration at a remote posttraumatic stage, including progressing brain gliosis. Even after the 60 days posttraumatic stage, brain structures were not normalized either in the traumatic or in contralateral hemisphere, also in the neurons of the hypothalamus.