Increased levels of c-fos and c-myc mRNA in ATP-stimulated endothelial cells
Copyright policy )Increased levels of c-fos and c-myc mRNA in ATP-stimulated endothelial cells
In bovine aortic endothelial cells, ATP induced a transient and sequential accumulation of c-fos and c-myc mRNA, which was detected after 1 hour and 3 hours, respectively. The effect of ATP on c-fos mRNA was stronger than that of TNF and bFGF. Both ATP and bFGF increased c-myc mRNA after a 3 hour treatment, whereas TNF did not. If none of the 3 agonists tested induced a selective expression of c-fos or c-myc, each of them was associated with a different quantitative combination of the 2 signals, which might be related to the distinct responses that they trigger in endothelial cells.
- Université Libre de Bruxelles Belgium
Proto-Oncogene Proteins -- genetics, Adenosine Triphosphate -- pharmacology, Cycloheximide -- pharmacology, Cells, Vascular -- enzymology, Messenger -- genetics, Fibroblast Growth Factor 2 -- pharmacology, Proto-Oncogene Proteins c-myc, Adenosine Triphosphate, Proto-Oncogene Proteins, Proto-Oncogenes, Tumor Necrosis Factor-alpha -- pharmacology, Animals, Northern, Endothelium, RNA, Messenger, Cycloheximide, Cells, Cultured, Cultured, Blotting, Tumor Necrosis Factor-alpha, Proto-Oncogene Proteins c-myc -- genetics, Vascular -- drug effects, Endothelium, Vascular -- enzymology, Protein-Tyrosine Kinases -- genetics, Sciences bio-médicales et agricoles, Protein-Tyrosine Kinases, Blotting, Northern, Kinetics, Proto-Oncogenes -- drug effects, Endothelium, Vascular -- drug effects, RNA, Cattle, Fibroblast Growth Factor 2, Endothelium, Vascular, Proto-Oncogene Proteins c-fos, RNA, Messenger -- genetics
Proto-Oncogene Proteins -- genetics, Adenosine Triphosphate -- pharmacology, Cycloheximide -- pharmacology, Cells, Vascular -- enzymology, Messenger -- genetics, Fibroblast Growth Factor 2 -- pharmacology, Proto-Oncogene Proteins c-myc, Adenosine Triphosphate, Proto-Oncogene Proteins, Proto-Oncogenes, Tumor Necrosis Factor-alpha -- pharmacology, Animals, Northern, Endothelium, RNA, Messenger, Cycloheximide, Cells, Cultured, Cultured, Blotting, Tumor Necrosis Factor-alpha, Proto-Oncogene Proteins c-myc -- genetics, Vascular -- drug effects, Endothelium, Vascular -- enzymology, Protein-Tyrosine Kinases -- genetics, Sciences bio-médicales et agricoles, Protein-Tyrosine Kinases, Blotting, Northern, Kinetics, Proto-Oncogenes -- drug effects, Endothelium, Vascular -- drug effects, RNA, Cattle, Fibroblast Growth Factor 2, Endothelium, Vascular, Proto-Oncogene Proteins c-fos, RNA, Messenger -- genetics
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).28 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!