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Journal of Neurology
Article . 2024 . Peer-reviewed
License: CC BY
Data sources: Crossref
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Other literature type . 2024
License: CC BY
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Narrative review of diagnosis, management and treatment of dysphagia and sialorrhea in amyotrophic lateral sclerosis

Authors: Bogdan Bjelica; Susanne Petri;

Narrative review of diagnosis, management and treatment of dysphagia and sialorrhea in amyotrophic lateral sclerosis

Abstract

AbstractThe degenerative motor neuron disorder amyotrophic lateral sclerosis (ALS) frequently leads bulbar symptoms like dysarthria, dysphagia, and sialorrhea, in approximately one-third of cases being the initial symptom. Throughout the disease, more than two-thirds of ALS patients experience dysphagia, regardless of the region of onset. In this review, we aimed to offer an updated overview of dysphagia and sialorrhea in ALS, covering its diagnosis, monitoring, and treatment in clinical practice. Regular assessment of dysphagia and sialorrhea during each patient visit is essential and should be a standard aspect of ALS care. Early discussion of potential treatments such as high-calorie diets or percutaneous endoscopic gastrostomy (PEG) is crucial. Furthermore, this review highlights and discusses potential areas for improvement in both clinical practice and research.

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Keywords

Amyotrophic lateral sclerosis ; Sialorrhea/therapy [MeSH] ; Humans [MeSH] ; Sialorrhea ; Dysphagia ; Disease Management [MeSH] ; Amyotrophic Lateral Sclerosis/diagnosis [MeSH] ; Amyotrophic Lateral Sclerosis/complications [MeSH] ; Motor neuron disease ; Deglutition Disorders/physiopathology [MeSH] ; Sialorrhea/diagnosis [MeSH] ; Sialorrhea/etiology [MeSH] ; ALS ; Deglutition Disorders/therapy [MeSH] ; Review ; Deglutition Disorders/diagnosis [MeSH] ; Amyotrophic Lateral Sclerosis/therapy [MeSH] ; Deglutition Disorders/etiology [MeSH], Amyotrophic Lateral Sclerosis, Humans, Disease Management, Review, Sialorrhea, Deglutition Disorders

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    4
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Top 10%
Average
Average
Green
hybrid