An emerging threat vector, embedded malware inside popular document formats, has become rampant since 2008. Owed to its wide-spread use and Javascript support, PDF has been the primary vehicle for delivering embedded exploits. Unfortunately, existing defenses are limited in effectiveness, vulnerable to evasion, or computationally expensive to be employed as an on-line protection system. In this paper, we propose a context-aware approach for detection and confinement of malicious Javascript in PDF. Our approach statically extracts a set of static features and inserts context monitoring code into a document. When an instrumented document is opened, the context monitoring code inside will cooperate with our runtime monitor to detect potential infection attempts in the context of Javascript execution. Thus, our detector can identify malicious documents by using both static and runtime features. To validate the effectiveness of our approach in a real world setting, we first conduct a security analysis, showing that our system is able to remain effective in detection and be robust against evasion attempts even in the presence of sophisticated adversaries. We implement a prototype of the proposed system, and perform extensive experiments using 18623 benign PDF samples and 7370 malicious samples. Our evaluation results demonstrate that our approach can accurately detect and confine malicious Javascript in PDF with minor performance overhead.