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Frontiers in Genetics
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Association prediction of lncRNAs and diseases using multiview graph convolution neural network

Authors: Wei Zhang; Yifu Zeng; Xiaowen Xiang; Bihai Zhao; Sai Hu; Limiao Li; Xiaoyu Zhu; +1 Authors

Association prediction of lncRNAs and diseases using multiview graph convolution neural network

Abstract

Long noncoding RNAs (lncRNAs) regulate physiological processes via interactions with macromolecules such as miRNAs, proteins, and genes, forming disease-associated regulatory networks. However, predicting lncRNA-disease associations remains challenging due to network complexity and isolated entities. Here, we propose MVIGCN, a graph convolutional network (GCN)-based method integrating multimodal data to predict these associations. Our framework constructs a heterogeneous network combining disease semantics, lncRNA similarity, and miRNA-lncRNA-disease interactions to address isolation issues. By modeling topological features and multiscale relationships through deep learning with attention mechanisms, MVIGCN prioritizes critical nodes and edges, enhancing prediction accuracy. Cross-validation demonstrated improved reliability over single-view methods, highlighting its potential to identify disease-related lncRNA biomarkers. This work advances network-based computational strategies for decoding lncRNA functions in disease biology and provides a scalable tool for prioritizing therapeutic targets.

Keywords

similarity network, graph convolutional network, multiview data, Genetics, deep learning, QH426-470, lncRNA-miRNA

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green
gold