A comparative analysis of the clinicoparaclinical manifestations of hepatobiliary pathology in 66 children, living under different ecological conditions has been carried out. It has been found out that ecologically conditioned pathology is of a nonspecific, polysystemic character in examined children. A high rate of early manifestations of hepatobiliary pathology has been diagnosed in the patients due to their living in the region contaminated by oil-processing products. The findings of the research have shown that a possible manifestation of a dysfunction of the hepatobiliary system in children from an ecologically unfavourable region is the onset of the biochemical signs of the syndrome of cholestasis.