In line with the Sustainable Development Goals (SDGs), the Infant Mortality Rate (AKB) is a very important health indicator, especially in neonatal and perinatal care. West Java Province consistently ranks third nationally in terms of infant mortality in 2020 and 2021. This study analyzes the factors influencing infant mortality in West Java in 2022 using secondary data from the 2022 West Java Provincial Health Profile. The response variable is the number of infant deaths, while the predictor variables include the percentage of K-4 coverage (X1), high-risk pregnancy (X2), family with PHBS (X3), exclusive breastfeeding (X4), and complete immunization coverage (X5). Given the count-based nature of the data, Poisson regression was used, which assumes equidispersion where the variance is equal to the mean. However, the analysis found overdispersion, where the variance significantly exceeds the mean, making Poisson regression unsuitable. To address this, Generalized Poisson Regression (GPR) was applied, as GPR introduces a dispersion parameter that accounts for overdispersion, thus better fitting the data. The initial Poisson regression results showed that X1, X2, X4, and X5 significantly influenced infant mortality, while the GPR model showed that only X2 and X3 were significant factors, with a dispersion parameter of -3.116. The GPR model shows that every additional one high-risk pregnancy increases the infant mortality rate by 1.00006, while an increase of one unit of clean and healthy living practices reduces the mortality rate by 2.66%. Model evaluation using AIC, BIC, and RMSE confirmed that the GPR model better described the relationship between predictor variables and infant mortality rates compared to Poisson regression. These findings emphasize the need to use GPR to model cases with overdispersion in count data, so as to provide more reliable information for policy and intervention strategies.