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Bone marrow disease in rhabdomyosarcoma visualized by 2-[18F]fluorodeoxyglucose positron emission tomography/computed tomography

Authors: Pia Kröning; Sebastian Berg; Martin T Freitag; Reineke A Schoot; Alexandra Fischer; Alexander Puzik; T Feuchtinger; +4 Authors

Bone marrow disease in rhabdomyosarcoma visualized by 2-[18F]fluorodeoxyglucose positron emission tomography/computed tomography

Abstract

AbstractBone marrow metastases—noted in 6% of patients with rhabdomyosarcoma—have been linked to very poor outcomes. Bilateral bone marrow sampling from iliac crests has been the gold standard for bone marrow examination in rhabdomyosarcoma, but sampling errors due to patchy bone marrow involvement may limit its sensitivity. Here, we report the case of a 6-year-old boy with embryonal rhabdomyosarcoma of the skull base and multiple 2-[18F]fluoro-2-deoxy-D-glucose (2-[18F]FDG)-avid bone marrow metastases visualized by positron emission tomography and computed tomography (2-[18F]FDG PET/CT). His bone marrow aspirates were tumor-free. This case illustrates the diagnostic value of 2-[18F]FDG PET/CT in the detection of bone marrow metastases in rhabdomyosarcoma patients, which may re-shape the definition of bone marrow disease and, ultimately, alter disease staging and risk stratification.

Country
Germany
Keywords

Male, ddc:610, Flurodeoxyglucose F18 ; Pediatrics ; Bone marrow metastases ; Rhabdomyosarcoma/diagnostic imaging [MeSH] ; Humans [MeSH] ; Radiopharmaceuticals [MeSH] ; Positron emission tomography computed tomography ; Rhabdomyosarcoma ; Fluorodeoxyglucose F18 [MeSH] ; Bone Marrow Neoplasms/diagnostic imaging [MeSH] ; Male [MeSH] ; Bone Marrow Neoplasms/pathology [MeSH] ; Positron Emission Tomography Computed Tomography/methods [MeSH] ; Rhabdomyosarcoma/pathology [MeSH] ; Child [MeSH] ; Case Report, 610, Case Report, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Rhabdomyosarcoma, Humans, Radiopharmaceuticals, Child, Bone Marrow Neoplasms, info:eu-repo/classification/ddc/610

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
Green
hybrid