Introduction: Increased cancer survivorship has prompted focus on optimising quality of life, including work reintegration. Despite frequently cited return-to-work barriers for women with breast cancer, there are no conclusive work-focused interventions for this cohort. The aim of this study was to assess feasibility and acceptability of a self-management intervention supporting return-to-work for women with breast cancer. Methods: A mixed-methods single-arm feasibility study evaluated intervention feasibility. Participants completed an online occupational therapy-led ‘Work and Cancer’ intervention over 6 weeks. Feasibility was determined by recruitment, adherence, retention and acceptability. Acceptability was also assessed through semi-structured interviews. Data were analysed using descriptive statistics and thematic analysis. Results: Ten out of twelve participants who were approached, participated in the study. Retention and adherence was 100% and 90%, respectively. Every participant completed pre- and post-measures. Qualitative data indicated online and group format as enablers to intervention completion and juggling employment as a barrier. Conclusion: It is feasible to recruit and retain participants to the ‘Work and Cancer’ intervention which was widely accepted by women with breast cancer. Large-scale evaluation will determine intervention effectiveness on work and health-related outcomes.