THE STUDY OF MECHANISMS OF PHOTOINDUCED APOPTOSIS IN THE SKIN MALIGNANT MELANOMA CELL MODEL

descriptionPublicationkeyboard_double_arrow_right Article 02 Dec 2016Publisher:Russian Photodynamic AssociationJournal:Biomedical Photonics, volume 5, pages 4-8 (issn: 2413-9432,

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Authors: M. L. Gelfond; I. A. Baldueva; A. S. Barchuk; G. I. Gafton; V. V. Anisimov; Yu. V. Semiletova; A. V. Novik; +6 Authors

doi: 10.24931/2413-9432-2016-5-3-4-8

THE STUDY OF MECHANISMS OF PHOTOINDUCED APOPTOSIS IN THE SKIN MALIGNANT MELANOMA CELL MODEL

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Abstract

The results of the experimental study of immune response of human skin malignant melanoma cells Mel 226 on photodynamic exposure are represented in the article. Photoinduced apoptosis of skin malignant melanoma was studied in vitro. The study showed that irradiation with the agent fotoditazin at dose of 0.5–2.5 µg/ml (6 and 10 min exposure 30 min before irradiation; irradiation parameters: wavelength of 662 nm, total light dose from 40 to 60 J/cm2) induced early apoptosis. The increase of the time of laser irradiation signiﬁcantly accelerates the conversion of photosensitized tumor cells from early to late apoptosis.

Related Organizations

North-Western State Medical University named after I.I. Mechnikov
Russian Federation
St Petersburg University
Russian Federation

Keywords

фото-дитазин, apoptosis, иммунный ответ, human skin malignant melanoma, immune response, фотодинамическое воздействие, apoptotic index, апоптоз, Medical technology, апоптический индекс, R855-855.5, photodynamic exposure, меланома кожи человека, fotoditazin

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