OBJECTIVE: Systematically integrate nurses’ experience with “Internet Nursing Service” to analysis the nurses’ experiences with “Internet Nursing Service”, and to provide a theoretical reference for formulating a more rational “Internet Nursing Service” model. METHODS: A systematic search in PubMed, Embase, Web of Science, the Cochrane Library, CINAHL, China National Knowledge Infrastructure (CNKI), Wanfang Database, and Chinese Biomedical Literature Database was conducted to collect qualitative research on nurses’ experiences with “Internet Nursing Service,” with a retrieval time limit from December 2019 to June 2024. Qualitative meta-synthesis was performed through line-by-line coding of relevant quotes, organization of codes into descriptive themes, and development of analytical themes. RESULTS: A total of 19 studies were included, one study was rated as Grade A in quality evaluation, and the remaining studies were rated as Grade B. Collectively synthesized into three integrated results: Harvest and growth, Difficulties and challenges, and Expectations and support. Harvest and growth, include 1) manifestation of self-value, 2) enhancing nursing capabilities, 3) optimizing nursing resources; Difficulties and challenges, include 1) lack of safety guarantee, 2) role conflict; Expectations and support include, 1) expectation for professional knowledge and skill training, 2) expectations for service platform optimization, 3) expectation for reasonable charges, 4) expectation for related policy support. CONCLUSION: “Internet Nursing Service” model benefits both nurses and patients, but still full of challenges. It aids in the decentralization of medical resources. Management departments still need to encourage nurses to actively invest in “Internet Nursing Service” while ensuring their safety and interests.