Involvement of the cyclic AMP-responsive element binding protein in bovine leukemia virus expression in vivo
Copyright policy )Involvement of the cyclic AMP-responsive element binding protein in bovine leukemia virus expression in vivo
The TAR element (Tax-responsive element; also called TxRE) is a major determinant of the regulation of bovine leukemia virus (BLV) expression. In order to gain insight into the mechanisms of viral expression, complexes formed between proteins and the TAR enhancer DNA were analyzed by gel retardation assays. We report here that nuclear lysates from ex vivo-isolated B lymphocytes contain proteins that specifically bind to TAR. An antibody directed toward the cyclic AMP-responsive element binding (CREB) protein supershifted a complex (C1) present only in BLV-infected B lymphocytes. The CREB protein thus appears to be a major transcription factor involved in BLV expression in vivo.
- University of Liège Belgium
- Boston University Brussels Belgium
- Université Libre de Bruxelles Belgium
Gene Expression Regulation, Viral, Cyclic AMP Response Element-Binding Protein -- metabolism, Enhancer Elements, Bovine -- genetics, Molecular Sequence Data, Regulatory Sequences, Nucleic Acid, Repetitive Sequences, Receptors, Cyclic AMP, B-Lymphocytes -- physiology, Veterinary medicine & animal health, Genetic, Receptors, Cyclic AMP, Leukemia Virus, Bovine, Animals, Viral, Cyclic AMP Response Element-Binding Protein, Repetitive Sequences, Nucleic Acid, B-Lymphocytes, Nucleic Acid, Base Sequence, Nuclear Proteins, Leukemia Virus, Sciences bio-médicales et agricoles, Life sciences, Médecine vétérinaire & santé animale, DNA-Binding Proteins, Enhancer Elements, Genetic, Gene Expression Regulation, Oligodeoxyribonucleotides -- metabolism, Oligodeoxyribonucleotides, Cyclic AMP -- physiology, Sciences du vivant, Cattle, Nuclear Proteins -- metabolism, Regulatory Sequences, DNA-Binding Proteins -- metabolism
Gene Expression Regulation, Viral, Cyclic AMP Response Element-Binding Protein -- metabolism, Enhancer Elements, Bovine -- genetics, Molecular Sequence Data, Regulatory Sequences, Nucleic Acid, Repetitive Sequences, Receptors, Cyclic AMP, B-Lymphocytes -- physiology, Veterinary medicine & animal health, Genetic, Receptors, Cyclic AMP, Leukemia Virus, Bovine, Animals, Viral, Cyclic AMP Response Element-Binding Protein, Repetitive Sequences, Nucleic Acid, B-Lymphocytes, Nucleic Acid, Base Sequence, Nuclear Proteins, Leukemia Virus, Sciences bio-médicales et agricoles, Life sciences, Médecine vétérinaire & santé animale, DNA-Binding Proteins, Enhancer Elements, Genetic, Gene Expression Regulation, Oligodeoxyribonucleotides -- metabolism, Oligodeoxyribonucleotides, Cyclic AMP -- physiology, Sciences du vivant, Cattle, Nuclear Proteins -- metabolism, Regulatory Sequences, DNA-Binding Proteins -- metabolism
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