Membrane on a Chip: A Functional Tethered Lipid Bilayer Membrane on Silicon Oxide Surfaces
Copyright policy )Membrane on a Chip: A Functional Tethered Lipid Bilayer Membrane on Silicon Oxide Surfaces
Tethered membranes have been proven during recent years to be a powerful and flexible biomimetic platform. We reported in a previous article on the design of a new architecture based on the self-assembly of a thiolipid on ultrasmooth gold substrates, which shows extremely good electrical sealing properties as well as functionality of a bilayer membrane. Here, we describe the synthesis of lipids for a more modular design and the adaptation of the linker part to silane chemistry. We were able to form a functional tethered bilayer lipid membrane with good electrical sealing properties covering a silicon oxide surface. We demonstrate the functional incorporation of the ion carrier valinomycin and of the ion channel gramicidin.
- Forschungszentrum Jülich Germany
- Flinders University Australia
- University of Florida United States
- Max Planck Society Germany
- Max Planck Institute for Polymer Research Germany
Time Factors, Phytol: chemistry, Lipid Bilayers, Microscopy, Atomic Force, Gramicidin: pharmacology, Ion Channels, Substrate Specificity, Ion Channels: chemistry, Phytol, Valinomycin: chemistry, Electric Impedance, Electrochemistry, Silanes: metabolism, Phosphatidylcholines: chemistry, 0306 Physical Chemistry (incl. Structural), info:eu-repo/classification/ddc/570, Valinomycin, Temperature, Silanes, Silicon Dioxide, Lipids, Lipid Bilayers: chemistry, Ionophores: pharmacology, J, Biophysics: methods, Spectrophotometry, Phosphatidylcholines, 2,3-di-O-phytanyl-sn-glycerol-1-tetraethylene glycol-(3-chloro-dimethylpropyl-silane) ether lipid, Silicon, Biophysics, Protein Array Analysis, Silicon: chemistry, Silicon Dioxide: chemistry, Lipid Bilayers: metabolism, Ions, Ionophores, Gramicidin, 2,3-di-O-phytanyl-sn-glycerol-1-tetraethylene glycol-(3-trichloropropyl-silane) ether lipid, Models, Chemical, Gold: chemistry, Lipids: chemistry, 1,2-diphytanoylphosphatidylcholine, Silanes: chemistry, Valinomycin: pharmacology, Gold, Protein Array Analysis: methods
Time Factors, Phytol: chemistry, Lipid Bilayers, Microscopy, Atomic Force, Gramicidin: pharmacology, Ion Channels, Substrate Specificity, Ion Channels: chemistry, Phytol, Valinomycin: chemistry, Electric Impedance, Electrochemistry, Silanes: metabolism, Phosphatidylcholines: chemistry, 0306 Physical Chemistry (incl. Structural), info:eu-repo/classification/ddc/570, Valinomycin, Temperature, Silanes, Silicon Dioxide, Lipids, Lipid Bilayers: chemistry, Ionophores: pharmacology, J, Biophysics: methods, Spectrophotometry, Phosphatidylcholines, 2,3-di-O-phytanyl-sn-glycerol-1-tetraethylene glycol-(3-chloro-dimethylpropyl-silane) ether lipid, Silicon, Biophysics, Protein Array Analysis, Silicon: chemistry, Silicon Dioxide: chemistry, Lipid Bilayers: metabolism, Ions, Ionophores, Gramicidin, 2,3-di-O-phytanyl-sn-glycerol-1-tetraethylene glycol-(3-trichloropropyl-silane) ether lipid, Models, Chemical, Gold: chemistry, Lipids: chemistry, 1,2-diphytanoylphosphatidylcholine, Silanes: chemistry, Valinomycin: pharmacology, Gold, Protein Array Analysis: methods
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