Bam-dependent deubiquitinase complex can disrupt germ-line stem cell maintenance by targeting cyclin A
Copyright policy )Bam-dependent deubiquitinase complex can disrupt germ-line stem cell maintenance by targeting cyclin A
Significance Previous studies have demonstrated that Bam protein plays a critical role promoting early germ-line cell differentiation in the Drosophila ovary. Although its regulation and genetic functions have been extensively investigated over the last 20 years, the biochemical nature of Bam has still remained elusive. Here, we show that Bam functions as an ubiquitin-associated protein and regulates the stability of CycA. Our study uncovers a mechanism by which Bam functions as an ubiquitin-associated protein, and cooperates with Otu to deubiquitinate and stabilize CycA, thereby balancing GSC self-renewal and differentiation.
- Anhui Agricultural University China (People's Republic of)
- University of Copenhagen Denmark
- Institute of Zoology China (People's Republic of)
- Zhejiang Ocean University China (People's Republic of)
- University of Copenhagen Denmark
Ovary/cytology, Genetically Modified, Cyclin A, Animals, Genetically Modified, Drosophila Proteins/antagonists & inhibitors, Cyclin A/chemistry, Cell Self Renewal/physiology, Deubiquitinating Enzymes/metabolism, Stem Cells/cytology, Cell Differentiation/physiology, Animals, Drosophila Proteins, Protein Interaction Domains and Motifs, Cell Self Renewal, Germ Cells/cytology, Deubiquitinating Enzymes, Protein Stability, Ubiquitin, Stem Cells, Ovary, Cell Differentiation, Drosophila melanogaster, Germ Cells, Gene Knockdown Techniques, Drosophila melanogaster/cytology, Female, Ubiquitin/metabolism
Ovary/cytology, Genetically Modified, Cyclin A, Animals, Genetically Modified, Drosophila Proteins/antagonists & inhibitors, Cyclin A/chemistry, Cell Self Renewal/physiology, Deubiquitinating Enzymes/metabolism, Stem Cells/cytology, Cell Differentiation/physiology, Animals, Drosophila Proteins, Protein Interaction Domains and Motifs, Cell Self Renewal, Germ Cells/cytology, Deubiquitinating Enzymes, Protein Stability, Ubiquitin, Stem Cells, Ovary, Cell Differentiation, Drosophila melanogaster, Germ Cells, Gene Knockdown Techniques, Drosophila melanogaster/cytology, Female, Ubiquitin/metabolism
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