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Journal of Theoretical Biology
Article . 2019 . Peer-reviewed
License: Elsevier TDM
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On the number of driver nodes for controlling a Boolean network when the targets are restricted to attractors

Authors: Tatsuya Akutsu; Wai-Ki Ching; Wai-Ki Ching; Peiying Ruan; Wenpin Hou; Wenpin Hou;

On the number of driver nodes for controlling a Boolean network when the targets are restricted to attractors

Abstract

It is known that many driver nodes are required to control complex biological networks. Previous studies imply that O(N) driver nodes are required in both linear complex network and Boolean network models with N nodes if an arbitrary state is specified as the target. In order to cope with this intrinsic difficulty, we consider a special case of the control problem in which the targets are restricted to attractors. For this special case, we mathematically prove under the uniform distribution of states in basins that the expected number of driver nodes is only O(log2N+log2M) for controlling Boolean networks, where M is the number of attractors. Since it is expected that M is not very large in many practical networks, the new model requires a much smaller number of driver nodes. This result is based on discovery of novel relationships between control problems on Boolean networks and the coupon collector's problem, a well-known concept in combinatorics. We also provide lower bounds of the number of driver nodes as well as simulation results using artificial and realistic network data, which support our theoretical findings.

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Keywords

Controllability, coupon collector's problem, Systems Biology, Systems biology, networks, Models, Theoretical, controllability, Models, Biological, Boolean networks, driver nodes, Switching theory, application of Boolean algebra; Boolean functions, Algorithms

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
7
Top 10%
Average
Average
bronze