In the invited review by Paillard (2015), comprehensive information about both theoretical and empirical studies of Pleistocene glaciations and their causes are presented. D. Paillard's review concludes that Milankovitch, 1930 and Milankovitch, 1941 theory cannot explain the 100,000 yr periodicity of glaciations within the last one million years, and that an additional factor must be responsible for global climate fluctuations. According to Paillard (2015), changes in the carbon dioxide (CO2) content of the atmosphere are responsible. This statement radically alters the conventional viewpoint about the leading role of orbital variations on global Pleistocene climate (e.g., Hays et al., 1976). However, Paillard's (2015) conclusions cause serious objections. Furthermore, there are some inaccuracies in Paillard (2015) which lead to an incorrect representation of the development of orbital palaeoclimatic theory. This paradigm relates global climatic variations to orbital insolation variations, as put forward for example, by Adhemar, 1842 and Croll, 1875, and Milankovitch, 1930 and Milankovitch, 1941. In this Comment, we discuss the Paillard's (2015) viewpoints and their controversies.