The analysis of the main problems of studies of the organisms interaction with electromagnetic radiation in the microwave range is submitted. The controversial approach to assessing the role of microwave radiations of artificial origin for organisms is noted. One group of scientists considers these radiations as potentially dangerous to an organism, and the other group claims that under certain conditions they can be used in the medical purposes. The specified contradiction is eliminated by using exogenous approach to assessing the role of electromagnetic radiation in wildlife. In this regard in the article the operating role in the wildlife of the Sun microwave radiation reaching the surface of the Earth and the need for its simulation devices for reducing the negative impact on organisms of electromagnetic pollution is proved. The main results of microbiological studies using the developed hardware and software for simulation of the Sun microwave radiation in the superhigh-frequency range of wavelengths.