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Enhanced Immunogenicity and Protective Efficacy with the Use of Interleukin-12-Encapsulated Microspheres plus AS01B in Tuberculosis Subunit Vaccination

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2006 English Publisher:American Society for MicrobiologyJournal:Infection and Immunity, volume 74, pages 4,954-4,959 (issn: 0019-9567, eissn: 1098-5522, Copyright policy )
Authors: Ha, SJ; Park, SH; Kim, HJ; Kim, SC; Kang, HJ; Lee, EG; Kwon, SG; +5 Authors

doi: 10.1128/iai.01781-05

pmid: 16861689

pmc: PMC1539587

Enhanced Immunogenicity and Protective Efficacy with the Use of Interleukin-12-Encapsulated Microspheres plus AS01B in Tuberculosis Subunit Vaccination

Abstract

ABSTRACTTuberculosis subunit vaccines codelivered with interleukin-12 (IL-12)-encapsulated microspheres (IL-12EM) are designed for a sustained release of IL-12 and could induce strong Th1 immune responses specific to Ag85A and ESAT-6. The adjuvant combination of IL-12EM plus AS01B was a more efficient way to induce a sustained Th1 immunity and protection againstMycobacterium tuberculosis.

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Keywords

ANTIGEN, PLGA MICROSPHERES, Tuberculosis/prevention & control*, 610, Bacterial/blood*, Capsules, CONTROLLED-RELEASE, Inbred C57BL, Antibodies, Immunologic*, Mice, Adjuvants, Immunologic, Bacterial Proteins, Mycobacterium tuberculosis/pathogenicity, Bacterial/immunology, ANTITUMOR IMMUNITY, Tuberculosis Vaccines/immunology*, Animals, Tuberculosis, Th1 Cells/immunology, Adjuvants, Antigens, Tuberculosis Vaccines, Tuberculosis/immunology, Antigens, Bacterial, BIODEGRADABLE MICROSPHERES, INTERFERON-GAMMA, Vaccination, MEMORY CELLS, IN-VITRO, Mycobacterium tuberculosis, Tuberculosis Vaccines/administration & dosage, Th1 Cells, Microspheres*, Antibodies, Bacterial, Interleukin-12, Microspheres, Acyltransferases/immunology, Mice, Inbred C57BL, Delayed-Action Preparations, T-CELLS, Interleukin-12/immunology*, Mycobacterium tuberculosis/immunology, MYCOBACTERIUM-TUBERCULOSIS, Acyltransferases

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
32
Top 10%
Top 10%
Top 10%
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