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Diagnostic and therapeutic approach to acute blood pressure elevations: results of an international survey among excellence centres of the European society of hypertension

Authors: Buso, Giacomo; Weber, Thomas; Fragoulis, Christos; Grassi, Guido; Agabiti-Rosei, Claudia; Delles, Christian; Doumas, Michalis; +4 Authors

Diagnostic and therapeutic approach to acute blood pressure elevations: results of an international survey among excellence centres of the European society of hypertension

Abstract

Acute blood pressure (BP) elevations are common in emergency settings and are traditionally classified into hypertensive urgencies (HU) and hypertensive emergencies (HE). Malignant hypertension (MHT) represents a severe form of HE characterised by small vessel damage. Although international guidelines provide clear definitions and treatment strategies, real-world data have shown persistent fragmentation and heterogeneity in the diagnosis and management of these patients. A web-based, anonymous survey promoted by the European Society of Hypertension (ESH) was distributed among physicians from 18 European and 4 non-European countries. The questionnaire assessed definitions, diagnostic work-up, BP measurement practices, and therapeutic strategies for HU, HE, and MHT. Sixty–four participants in 56 centres completed the survey. HU was correctly defined as a severe BP elevation without acute clinically symptomatic hypertension-mediated organ damage (A-HMOD) by 45.3% of respondents. Small cuffs were available to 79.7% and extra-large cuffs to 70.3% of respondents.. Intravenous antihypertensive therapy was used for HE by 88.7% of participants, while 20.6% also used intravenous drugs for HU. Parenteral clonidine and sublingual nifedipine were prescribed by 29.7% and 26.6% of respondents, respectively. Definitions and therapeutic approaches for MHT varied substantially, with 62.9% adopting a recently proposed definition involving at least three target organ damages in patients with BP >200/120 mmHg. This international survey highlights considerable variability in the definition, diagnostic work-up, and therapeutic management of acute BP elevations, emphasising the need for harmonised protocols and further education. Sudden, severe increases in blood pressure (BP) are a common reason for emergency medical attention.These situations are classified into two groups: hypertensive emergencies (HE), which involve high BP with damage to vital organs (such as the brain, heart, or kidneys), and hypertensive urgencies (HU), where BP is very high but without immediate organ damage.Correct identification is important because HE requires urgent intravenous medication, while HU is usually treated with oral drugs.The European Society of Hypertension (ESH) conducted a survey among 64 doctors from 56 specialist centres in 22 countries. The aim was to understand how high BP episodes are diagnosed and treated in real-world settings.Results showed that doctors use different definitions for HU and HE, and not all follow the official guidelines.Many doctors still use medications not recommended in guidelines, such as sublingual nifedipine and intravenous drugs for HU.Availability of correct BP cuffs and diagnostic tools, like fundoscopy or imaging, varies widely.Only about half of the centres had a clear treatment protocol for managing acute BP increases.Definitions and treatment of malignant hypertension (a very severe form) also varied.The study highlights the need for clearer definitions, better training, and consistent clinical protocols. Improving these areas may reduce complications, avoid unnecessary treatments, and help patients receive more effective care. Sudden, severe increases in blood pressure (BP) are a common reason for emergency medical attention. These situations are classified into two groups: hypertensive emergencies (HE), which involve high BP with damage to vital organs (such as the brain, heart, or kidneys), and hypertensive urgencies (HU), where BP is very high but without immediate organ damage. Correct identification is important because HE requires urgent intravenous medication, while HU is usually treated with oral drugs. The European Society of Hypertension (ESH) conducted a survey among 64 doctors from 56 specialist centres in 22 countries. The aim was to understand how high BP episodes are diagnosed and treated in real-world settings. Results showed that doctors use different definitions for HU and HE, and not all follow the official guidelines. Many doctors still use medications not recommended in guidelines, such as sublingual nifedipine and intravenous drugs for HU. Availability of correct BP cuffs and diagnostic tools, like fundoscopy or imaging, varies widely. Only about half of the centres had a clear treatment protocol for managing acute BP increases. Definitions and treatment of malignant hypertension (a very severe form) also varied. The study highlights the need for clearer definitions, better training, and consistent clinical protocols. Improving these areas may reduce complications, avoid unnecessary treatments, and help patients receive more effective care.

Keywords

Humans; Antihypertensive Agents/therapeutic use; Hypertension/diagnosis; Hypertension/drug therapy; Hypertension/physiopathology; Europe; Surveys and Questionnaires; Blood Pressure/drug effects; Hypertension, Malignant/diagnosis; Hypertension, Malignant/drug therapy; Hypertension, Malignant/physiopathology; Male; Blood Pressure Determination; Female; Hypertensive emergencies; hypertensive urgencies; malignant hypertension; real-world management; treatment, treatment, Hypertensive emergencies; hypertensive urgencies; malignant hypertension; real-world management; treatment;, RC666-701, real-world management, hypertensive urgencies, Diseases of the circulatory (Cardiovascular) system, Hypertensive emergencies, malignant hypertension

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
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