Reaction of 2-(2,4-dichlorobenzydene)hydrazine-1-carbothioamide (L), triphenylphosphine with cuprous chloride, cuprous bromide and cuprous iodide, respectively, under the nitrogen atmosphere, afforded three new copper(I) complexes [CuClL(Ph3P)2]∙MeCN (1), [CuBrL(Ph3P)2]∙0.5EtOEt (2) and [CuIL(Ph3P)2] (3). The complexes have been characterized by means of single crystal X-ray crystallography and XPS. The ligand L in its neutral form coordinates to the Cu ion via S atom. The Cu atom in each complex is coordinated by one L, two PPh3 and one halide ligands, to form tetrahedral coordination. The XPS results are shown that the chemical valence state of copper in the product is +1. The complexes were evaluated for their urease inhibitory activity, and gave satisfactory results (IC50 = 13–19 μmol L–1).