Multiple myeloma (ММ) accounts for about 10 % of all hematologic tumors. The diversity of symptoms and variants of clinical course as well as a broad range of potential complications of both the disease itself and chemotherapy, indicate the need for further improvement of personalized treatment principles. The use of medical calculators (MC) integrating clinical, laboratory, and genetic data is becoming an important part of modern medical practice. The application of MC contributes to more credible assessment of the individual prognosis. Besides, current interest is attached to clinical decision support systems (CDSS) designed for the optimization of decision making. This paper reviews the major digital tools employed by professionals at all stages of management of patients with MM. They include laboratory diagnosis, disease staging, comorbidity assessment, complication risk, drug dosage calculations, and drug–drug interaction analysis. Special emphasis is laid on CDSS considering clinical and genetic characteristics of patients to ensure the optimal decision making on the treatment programs with regard to efficacy and safety. This paper provides practical recommendations on the application of the above tools in everyday clinical practice and contains the links to available online calculators and digital services. The implementation of MC and useful digital services facilitates better clinical outcomes, improves quality of life of patients, and optimizes healthcare resources as it contributes to efficacy and safety of MM treatment.