Article is devoted to analysis of the scientific, technical and innovative development of Ukraine for the purpose of identification of peculiarities of diffusion of innovations in the regions.Relevant issues of diffusion of innovations are generalized using results of the corresponding theoretical and practical studies, which were conducted in the countries with market economy and with the high level of information technology development. Peculiarities of diffusion of innovations in areas with different population density, scientific and business environments are considered. Indicators of scientific, technical and innovative development of the regions of Ukraine are analyzed using the method of principal components. Authors singled out from the general array of parameters specific indicators, which characterize the principal components of innovative development, among which there are levels of research activity, innovation activity, human and financial potential. Consolidation of regions depending on the level of indicators, which characterize the principal components of innovative development is performed. Correlation between the value of corresponding indicators and levels of urbanization and industrial development of the regions are clearly established.Grouping of regions of Ukraine depending on the level of development of a human capital, amounts of funding of R&D and innovation activities, level of implementation of innovative products and technologies in production is performed.Need of increasing the availability of disaggregated statistics related to innovation activity of the enterprises and scientific institutions in Ukraine is proved. Ways of acceleration of diffusion of innovations and regional alignment of indicators of innovative development in Ukraine are defined, including: strengthening of the state innovation policy to foster development of regional and industry networks of exchange of the innovation experience, knowledge, open information on new developments and possibilities of financing of the innovation projects; support of creation in rural territories of partnership around the innovation projects to ensure SME greening and rapid implementation of the latest innovation processes.