This article proposes a dynamic spiral scrambling algorithm, which is combined with the random pixel value filling operation, Deoxyribonucleic Acid (DNA) operation and used in image encryption. The random pixel value filling operation is to generate some random values and fill them around the plain-image. These values can influence all the pixels after the confusion and diffusion operations. The proposed dynamic spiral scrambling algorithm dynamically combines the chaotic sequences with the plaintext image, and scrambles the pixel values of the plaintext image, this operation makes the scrambling algorithm not fixed, and position changes are highly sensitive to the chaotic sequences, any slight change will get a completely different result. Then, this article combines Deoxyribonucleic Acid (DNA) coding and manipulation to further confuse pixel values. Finally, the average entropy is 7.9974, the average NPCR is 99.6067 and the average UACI is 33.4544, experimental results and various security analyses show that the algorithm has good encryption effects and can resist common attacks such as select plaintext attacks, cropping, and noise attacks.