Global and regional burden of chronic respiratory disease in 2016 arising from non-infectious airborne occupational exposures: a systematic analysis for the Global Burden of Disease Study 2016
Copyright policy )Global and regional burden of chronic respiratory disease in 2016 arising from non-infectious airborne occupational exposures: a systematic analysis for the Global Burden of Disease Study 2016
ObjectivesThis paper presents detailed analysis of the global and regional burden of chronic respiratory disease arising from occupational airborne exposures, as estimated in the Global Burden of Disease 2016 study.MethodsThe burden of chronic obstructive pulmonary disease (COPD) due to occupational exposure to particulate matter, gases and fumes, and secondhand smoke, and the burden of asthma resulting from occupational exposure to asthmagens, was estimated using the population attributable fraction (PAF), calculated using exposure prevalence and relative risks from the literature. PAFs were applied to the number of deaths and disability-adjusted life years (DALYs) for COPD and asthma. Pneumoconioses were estimated directly from cause of death data. Age-standardised rates were based only on persons aged 15 years and above.ResultsThe estimated PAFs (based on DALYs) were 17% (95% uncertainty interval (UI) 14%–20%) for COPD and 10% (95% UI 9%–11%) for asthma. There were estimated to be 519 000 (95% UI 441,000–609,000) deaths from chronic respiratory disease in 2016 due to occupational airborne risk factors (COPD: 460,100 [95% UI 382,000–551,000]; asthma: 37,600 [95% UI 28,400–47,900]; pneumoconioses: 21,500 [95% UI 17,900–25,400]. The equivalent overall burden estimate was 13.6 million (95% UI 11.9–15.5 million); DALYs (COPD: 10.7 [95% UI 9.0–12.5] million; asthma: 2.3 [95% UI 1.9–2.9] million; pneumoconioses: 0.58 [95% UI 0.46–0.67] million). Rates were highest in males; older persons and mainly in Oceania, Asia and sub-Saharan Africa; and decreased from 1990 to 2016.ConclusionsWorkplace exposures resulting in COPD, asthma and pneumoconiosis continue to be important contributors to the burden of disease in all regions of the world. This should be reducible through improved prevention and control of relevant exposures.
- University of Liège Belgium
- Bill & Melinda Gates Foundation United States
- University of Oxford United Kingdom
- University of Edinburgh United Kingdom
- University of Groningen Netherlands
Pneumoconiosis/epidemiology, Male, Persons with Disabilities, 1599 Other Commerce, GBD 2016 occupational chronic respiratory risk factors collaborators, Global Health, Global Burden of Disease, Pulmonary Disease, Chronic Obstructive, 1599 Other Commerce, Management, Tourism and Services, Risk Factors, METABOLIC RISKS, Human health sciences, Workplace, Public, Environmental & Occupational Health, Aged, 80 and over, STATEMENT, Public, Middle Aged, Management, COPD; occupational asthma; occupational exposure; pneumoconiosis; work, Respiration Disorders/epidemiology, PREVALENCE, Occupational Diseases, COMPARATIVE RISK-ASSESSMENT, Female, Quality-Adjusted Life Years, occupational asthma, Life Sciences & Biomedicine, Adult, pneumoconiosis, Adolescent, Public health, health care sciences & services, 610, Global Burden of Disease/statistics & numerical data, Sciences de la santé humaine, OBSTRUCTIVE PULMONARY-DISEASE, Risk Assessment, Santé publique, services médicaux & soins de santé, Environmental & Occupational Health, 1117 Public Health and Health Services, Young Adult, Age Distribution, Life Expectancy, work, Disabled Persons/statistics & numerical data, Occupational Exposure, COPD, Humans, Disabled Persons, Tourism and Services, Sex Distribution, Pulmonary Disease, Chronic Obstructive/epidemiology, Aged, Global Burden of Disease/trends, WORK, Global Health/trends, Science & Technology, ONSET ASTHMA, Occupational Exposure/adverse effects, Public Health, Environmental and Occupational Health, 1103 Clinical Sciences, occupational exposure, Respiration Disorders, Asthma, Global Health/statistics & numerical data, Occupational Diseases/epidemiology, Socioeconomic Factors, GBD 2016 Occupational Chronic Respiratory Risk Factors Collaborators, Chronic Disease, Asthma/epidemiology, NA, Pneumoconiosis, Occupational Exposure/statistics & numerical data, CLUSTERS, LUNG
Pneumoconiosis/epidemiology, Male, Persons with Disabilities, 1599 Other Commerce, GBD 2016 occupational chronic respiratory risk factors collaborators, Global Health, Global Burden of Disease, Pulmonary Disease, Chronic Obstructive, 1599 Other Commerce, Management, Tourism and Services, Risk Factors, METABOLIC RISKS, Human health sciences, Workplace, Public, Environmental & Occupational Health, Aged, 80 and over, STATEMENT, Public, Middle Aged, Management, COPD; occupational asthma; occupational exposure; pneumoconiosis; work, Respiration Disorders/epidemiology, PREVALENCE, Occupational Diseases, COMPARATIVE RISK-ASSESSMENT, Female, Quality-Adjusted Life Years, occupational asthma, Life Sciences & Biomedicine, Adult, pneumoconiosis, Adolescent, Public health, health care sciences & services, 610, Global Burden of Disease/statistics & numerical data, Sciences de la santé humaine, OBSTRUCTIVE PULMONARY-DISEASE, Risk Assessment, Santé publique, services médicaux & soins de santé, Environmental & Occupational Health, 1117 Public Health and Health Services, Young Adult, Age Distribution, Life Expectancy, work, Disabled Persons/statistics & numerical data, Occupational Exposure, COPD, Humans, Disabled Persons, Tourism and Services, Sex Distribution, Pulmonary Disease, Chronic Obstructive/epidemiology, Aged, Global Burden of Disease/trends, WORK, Global Health/trends, Science & Technology, ONSET ASTHMA, Occupational Exposure/adverse effects, Public Health, Environmental and Occupational Health, 1103 Clinical Sciences, occupational exposure, Respiration Disorders, Asthma, Global Health/statistics & numerical data, Occupational Diseases/epidemiology, Socioeconomic Factors, GBD 2016 Occupational Chronic Respiratory Risk Factors Collaborators, Chronic Disease, Asthma/epidemiology, NA, Pneumoconiosis, Occupational Exposure/statistics & numerical data, CLUSTERS, LUNG
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