descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2019 English Publisher:Elsevier BVJournal:Diagnostic Microbiology and Infectious Disease, volume 95, pages 144-148 (issn: 0732-8893,

Authors: Y Van der Beken; Y Van der Beken; D De Geyter; M Van Esbroeck;

doi: 10.1016/j.diagmicrobio.2019.05.004

pmid: 31171395

handle: 20.500.14017/47748518-3e73-49ea-83da-0e991544f3d5

Performance evaluation of the Diasorin LIAISON® XL Zika capture IgM CLIA test

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Abstract

Because Zika virus (ZIKV) can cause serious birth defects and is involved in cases of Guillain-Barré syndrome, the ZIKV outbreak in the American continent in 2015 resulted in an enormous need for ZIKV diagnostic tools. We evaluated the LIAISON® XL Zika Capture IgM test on 106 samples from patients, mainly travelers, with a confirmed or probable ZIKV infection. Sensitivity between 0 and 84 days after onset of symptoms was 92.5%. Specificity was evaluated on a panel of 56 samples known to cause possible cross-reactions. Cross-reaction with DENV antibodies was limited (10.5%) but false-positive results occurred in samples from patients with malaria, CMV and EBV infections.

Related Organizations

Vrije Universiteit Brussel
Belgium
Universitair Ziekenhuis Brussel
Belgium
Institute of Tropical Medicine Antwerp
Belgium

Keywords

Automation, Laboratory, Serologic Tests/methods, Zika Virus Infection/blood, Zika Virus Infection, Zika Virus, Cross Reactions, Immunoglobulin M/blood, Antibodies, Viral, Sensitivity and Specificity, Antibodies, Viral/blood, Zika Virus/immunology, Immunoglobulin M, Humans, Serologic Tests, Retrospective Studies

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