[Objective] Industrial parks serve as critical hubs for zero-waste construction and carbon emission reduction. However, previous studies lacked quantitative methods for evaluating the carbon mitigation benefits of solid waste management in these parks. Developing a quantitative evaluation framework for carbon reduction performance in zero-waste park development carries both theoretical and practical implications for standardizing the accounting of carbon reduction benefits in such parks. [Methods] A framework for the quantitative evaluation of carbon reduction performance in zero-waste industrial parks was developed based on material flow analysis (MFA) and life cycle assessment (LCA). The framework comprised six core steps: determining objectives and scope, establishing waste flow diagrams, selecting disposal technologies, investigating emission levels, identifying carbon reduction performance, and evaluating results with decision support. Additionally, two nested inner loops, measure improvement and emission control, were incorporated to dynamically track synergistic carbon reduction benefits and identify technical pathways for zero-waste park development. [Results] The proposed framework was empirically validated and demonstrated through a case study of an actual industrial park in Beijing E-Town. In 2022, the selected industrial park achieved a carbon reduction of 17000 tons through co-processing of hazardous waste in cement kilns. Additional reductions of 103 000 tons were realized by recycling general industrial sludge, scrap steel plates, and paper packaging or cartons. The accounted waste quantity represented approximately 50% of the total waste generated in the industrial park that year. [Conclusion] The proposed framework accommodates both park-specific and universal characteristics, making it applicable to various parks with diverse industrial structures, production processes, and waste generation characteristics. It upwardly aligns with “zero-waste city” construction and downwardly empowers zero-waste company development, thus facilitating coordinated decision-making for waste-free development and the achievement of the “dual carbon”goals.