
pmid: 33610120
handle: 20.500.11768/112715 , 2434/827690 , 10807/179308 , 11577/3396496 , 11573/1753666 , 11568/1083158 , 11697/158896 , 2158/1258280 , 2318/1858722 , 11586/371491
pmid: 33610120
handle: 20.500.11768/112715 , 2434/827690 , 10807/179308 , 11577/3396496 , 11573/1753666 , 11568/1083158 , 11697/158896 , 2158/1258280 , 2318/1858722 , 11586/371491
Oligometastatic Non-Small Cell Lung Cancer (NSCLC) patients represent a category without a standard therapeutic approach. However, in selected oligometastatic NSCLC, radical surgery seems to offer a good prognosis. This retrospective study aimed to analyse the long-term outcomes of synchronous oligometastatic patients treated with curative intent and identify the factors associated with better results and the proposal of a risk stratification system for classifying the synchronous oligometastatic NSCLC.The medical records of patients from 18 centres with pathologically diagnosed synchronous oligometastatic NSCLC were retrospectively reviewed. The inclusion criteria were synchronous oligometastatic NSCLC, radical surgical treatment of the primary tumour with or without neoadjuvant/adjuvant therapy and radical treatment of all metastatic sites. The Kaplan - Meier method estimated survivals. A stratified backward stepwise Cox regression model was assessed for multivariable survival analyses.281 patients were included. The most common site of metastasis was the brain, in 50.89 % patients. Median overall survival was 40 months (95 % CI: 29-53). Age ≤65 years (HR = 1.02, 95 % CI: 1.00-1.05; p = 0.019), single metastasis (HR = 0.71, 95 % CI: 0.45-1.13; p = 0.15) and presence of contralateral lung metastases (HR = 0.30, 95 % CI: 0.15 - 0.62; p = 0.001) were associated with a good prognosis. The presence of pathological N2 metastases negatively affected survival (HR = 2.00, 95 % CI: 1.21-3.32; p = 0.0065). These prognostic factors were used to build a simple risk classification scheme.Treatment of selected synchronous oligometastatic NSCLC with curative purpose could be conducted safely and at acceptable 5-year survival levels, especially in younger patients with pN0 disease.
Lung Neoplasms, Prognosi, Biostatistic, 610, Risk classification, Kaplan-Meier Estimate, Biostatistics, Risk Assessment, Oligometastatic, Retrospective Studie, Carcinoma, Non-Small-Cell Lung, Humans, Non-Small-Cell Lung, Lung cancer; Oligometastatic; Thoracic surgery; Lung Neoplasms, Aged, Retrospective Studies, Biostatistics; Lung cancer; Oligometastatic; Risk classification; Thoracic surgery; Aged; Humans; Kaplan-Meier Estimate; Prognosis; Retrospective Studies; Risk Assessment; Treatment Outcome; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms, Carcinoma, Prognosis, Thoracic surgery, Treatment Outcome, Lung cancer, Biostatistics; Lung cancer; Oligometastatic; Risk classification; Thoracic surgery, Human
Lung Neoplasms, Prognosi, Biostatistic, 610, Risk classification, Kaplan-Meier Estimate, Biostatistics, Risk Assessment, Oligometastatic, Retrospective Studie, Carcinoma, Non-Small-Cell Lung, Humans, Non-Small-Cell Lung, Lung cancer; Oligometastatic; Thoracic surgery; Lung Neoplasms, Aged, Retrospective Studies, Biostatistics; Lung cancer; Oligometastatic; Risk classification; Thoracic surgery; Aged; Humans; Kaplan-Meier Estimate; Prognosis; Retrospective Studies; Risk Assessment; Treatment Outcome; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms, Carcinoma, Prognosis, Thoracic surgery, Treatment Outcome, Lung cancer, Biostatistics; Lung cancer; Oligometastatic; Risk classification; Thoracic surgery, Human
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| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 10% |
