Identification of Siglec-1-negative alveolar macrophages with proinflammatory phenotypes in chronic obstructive pulmonary disease
Copyright policy )Identification of Siglec-1-negative alveolar macrophages with proinflammatory phenotypes in chronic obstructive pulmonary disease
Alveolar macrophages (AMs) in patients with chronic obstructive pulmonary disease (COPD) orchestrate persistent inflammation in the airway. We find that Siglec-1-negative alveolar macrophages have a wide range of proinflammatory landscapes and a protease-expressing phenotype. Moreover, this subset is associated with the pathogenesis of COPD and responds to viral stimuli.
- Tohoku University Japan
- University of Salford United Kingdom
- Osaki Citizen Hospital Japan
Male, Inflammation, Sialic Acid Binding Ig-like Lectin 1/metabolism, Sialic Acid Binding Ig-like Lectin 1, Macrophages, Chronic Obstructive/metabolism, Inflammation/metabolism, Cytokines/metabolism, Alveolar/metabolism, Middle Aged, Pulmonary Disease, Pulmonary Disease, Chronic Obstructive, Phenotype, Macrophages, Alveolar, Pulmonary Disease, Chronic Obstructive/metabolism, Humans, Cytokines, Female, Macrophages, Alveolar/metabolism, Aged
Male, Inflammation, Sialic Acid Binding Ig-like Lectin 1/metabolism, Sialic Acid Binding Ig-like Lectin 1, Macrophages, Chronic Obstructive/metabolism, Inflammation/metabolism, Cytokines/metabolism, Alveolar/metabolism, Middle Aged, Pulmonary Disease, Pulmonary Disease, Chronic Obstructive, Phenotype, Macrophages, Alveolar, Pulmonary Disease, Chronic Obstructive/metabolism, Humans, Cytokines, Female, Macrophages, Alveolar/metabolism, Aged
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