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Nanotheranostics
Article . 2025 . Peer-reviewed
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Repository of the Czech Academy of Sciences
Article . 2025
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Combined physical and biological contributions to radiotherapy enhancement by Lu-based nanoscintillators in pancreatic cancer models

descriptionPublicationkeyboard_double_arrow_right Article 23 Jun 2025 English Publisher:Ivyspring International PublisherJournal:Nanotheranostics, volume 9, pages 199-215 (issn: 2206-7418, Copyright policy )
Authors: Stelse-Masson, Sarah; Lytvynenko, Xenie; Bedregal-Portugal, Kristel; Aubrun, Clémentine; Lavaud, Matéo; Kadri, Malika; Jacquet, Thibault; +9 Authors

doi: 10.7150/ntno.115120

handle: 11104/0369246

Combined physical and biological contributions to radiotherapy enhancement by Lu-based nanoscintillators in pancreatic cancer models

Abstract

Pancreatic cancer has a dismal prognosis and requires better treatments. One promising approach aims at improving radiotherapy using nanoscintillators, triggering various radiotherapeutic effects upon X-ray irradiation, such as radiation dose-enhancement. In this paper, we study the ability of Lu3Al5O12:Pr@SiO2, a lutetium-based nanoscintillator to exert a radiation dose-enhancement effect in two human pancreatic cancer cell models, namely PANC-1 and MIA PaCa-2. Our findings highlight the dual contribution of Lu3Al5O12:Pr@SiO2 nanoparticles to radiotherapy enhancement, combining both physical dose-enhancement and biological modulation of DNA repair.

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Keywords

radiation dose-enhancement, nanoscintillators, [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [SDV.CAN] Life Sciences [q-bio]/Cancer, pancreatic cancer models, Lu.sub.3./sub.Al.sub.5./sub.O.sub.12./sub.:Pr nanoparticles, pancreatic cancer, radiosensitization, radiotherapy, radiation dose enhancement

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
Green
gold
Related to Research communities
University Network for Innovation, Technology and Engineering
Cancer Research