The human brain is highly dynamic and complex, supporting a remarkable range of functions by dynamically integrating and coordinating different brain regions and networks across multiple spatial and temporal scales. Research on the human brain has become truly interdisciplinary involving medicine, neurobiology, engineering, and related fields. A thorough understanding of the mechanisms of neuromodulation actions is urgently needed for stimulation parameters optimization, response prediction, and consistent therapy. This Research Topic aims to combine top-down and bottom-up methods to produce robust results that allow for a meaningful interpretation in terms of the underlying brain dynamics with an emphasis on brain decoding and neuromodulation.