To introduce extra coding gain to Multi-input Multi-output (MIMO) system, how to combine MIMO and convolutional code (CC) was studied in two cases. In the first case, the type of MIMO was limited to pure spatial multiplexing. Then in the second case, the type was extended to the hybrid of spatial multiplexing and transmission diversity. Several encoding-decoding schemes were designed. For each scheme, its advantage and disadvantage were analyzed, and bit error rate performance was evaluated by simulation. Finally the scheme with best performance and acceptable complexity was elected from candidates for each case.