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Застосування імунобіологічних лікарських препаратів на основі моноклональних антитіл у нефрологічній практиці

Authors: Melnyk, O.O.;

Застосування імунобіологічних лікарських препаратів на основі моноклональних антитіл у нефрологічній практиці

Abstract

При різних захворюваннях нирок успішно застосовується імунобіологічна терапія на основі моноклональних антитіл із різним механізмом дії. До таких лікарських засобів належать: ритуксимаб (взаємодія з рецептором CD20 і елімінування В-клітин), екулізумаб (інгібування розщеплення С5 комплементу), буросумаб (блокування фактора росту фібробластів FGF23), адалімумаб (анти-TNF-α агент), абатацепт (блокує костимуляцію Т-клітин шляхом зв’язування з CD80), фрезолімумаб (нейтралізація TGF-β). Ці лікарські засоби застосовуються при системних захворюваннях нирок, фокально-сегментарному гломерулосклерозі, вовчаковому нефриті, мембранозній нефропатії, при трансплатації нирки.

Keywords

заболевания почек; моноклональные антитела; ритуксимаб; экулизумаб; буросумаб; адалимумаб; абатацепт; фрезолимумаб, abatacept, захворювання нирок; моноклональні антитіла; ритуксимаб; екулізумаб; буросумаб; адалімумаб; абатацепт; фрезолімумаб, kidney diseases, fresolimumab, Diseases of the genitourinary system. Urology, rituximab, adalimumab, burosumab, eculizumab, monoclonal antibodies, RC870-923, kidney diseases; monoclonal antibodies; rituximab; eculizumab; burosumab; adalimumab; abatacept; fresolimumab

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
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