LncRNA MIR31HG fosters stemness malignant features of non-small cell lung cancer via H3K4me1- and H3K27Ace-mediated GLI2 expression
Copyright policy )LncRNA MIR31HG fosters stemness malignant features of non-small cell lung cancer via H3K4me1- and H3K27Ace-mediated GLI2 expression
AbstractNon-coding RNAs are responsible for oncogenesis and the development of stemness features, including multidrug resistance and metastasis, in various cancers. Expression of lncRNA MIR31HG in lung cancer tissues and peripheral sera of lung cancer patients were remarkably higher than that of healthy individuals and indicated a poor prognosis. Functional analysis showed that MIR31HG fosters stemness-associated malignant features of non-small cell lung cancer cells. Further mechanistic investigation revealed that MIR31HG modulated GLI2 expression via WDR5/MLL3/P300 complex-mediated H3K4me and H3K27Ace modification. In vivo MIR31HG repression with an antisense oligonucleotide attenuated tumor growth and distal organ metastasis, whereas MIR31HG promotion remarkably encouraged cellular invasion in lung and liver tissues. Our data suggested that MIR31HG is a potential diagnostic indicator and druggable therapeutic target to facilitate multiple strategic treatments for lung cancer patients.
- Johannes Kepler University of Linz Austria
- Berlin Institute of Health at Charité Germany
- Freie Universität Berlin Germany
- Humboldt-Universität zu Berlin Germany
- Binzhou Medical University China (People's Republic of)
Male, Cancer Research, Lung Neoplasms, Lysine, Intracellular Signaling Peptides and Proteins, Nuclear Proteins, Zinc Finger Protein Gli2, Prognosis, Molecular Processes and Therapies [Topic 2], Article, Gene Expression Regulation, Neoplastic, Histones, Gene Expression Regulation, Neoplastic [MeSH] ; Cell Line, Tumor [MeSH] ; Carcinoma, Non-Small-Cell Lung/genetics [MeSH] ; Neoplastic Stem Cells/pathology [MeSH] ; Histones/genetics [MeSH] ; Lung Neoplasms/genetics [MeSH] ; RNA, Long Noncoding/genetics [MeSH] ; /38/90 ; Zinc Finger Protein Gli2/genetics [MeSH] ; /13/51 ; Intracellular Signaling Peptides and Proteins [MeSH] ; Male [MeSH] ; Lysine/analogs ; /13/100 ; /45/15 ; /631/67/1612/1350 ; /38/1 ; /631/80/304 ; /13/1 ; Carcinoma, Non-Small-Cell Lung/pathology [MeSH] ; Female [MeSH] ; Cell Proliferation [MeSH] ; Humans [MeSH] ; /42/109 ; /64/60 ; Nuclear Proteins/genetics [MeSH] ; Article ; Prognosis [MeSH] ; Lung Neoplasms/pathology [MeSH] ; /59 ; article, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Neoplastic Stem Cells, Humans, Female, RNA, Long Noncoding, Cell Proliferation
Male, Cancer Research, Lung Neoplasms, Lysine, Intracellular Signaling Peptides and Proteins, Nuclear Proteins, Zinc Finger Protein Gli2, Prognosis, Molecular Processes and Therapies [Topic 2], Article, Gene Expression Regulation, Neoplastic, Histones, Gene Expression Regulation, Neoplastic [MeSH] ; Cell Line, Tumor [MeSH] ; Carcinoma, Non-Small-Cell Lung/genetics [MeSH] ; Neoplastic Stem Cells/pathology [MeSH] ; Histones/genetics [MeSH] ; Lung Neoplasms/genetics [MeSH] ; RNA, Long Noncoding/genetics [MeSH] ; /38/90 ; Zinc Finger Protein Gli2/genetics [MeSH] ; /13/51 ; Intracellular Signaling Peptides and Proteins [MeSH] ; Male [MeSH] ; Lysine/analogs ; /13/100 ; /45/15 ; /631/67/1612/1350 ; /38/1 ; /631/80/304 ; /13/1 ; Carcinoma, Non-Small-Cell Lung/pathology [MeSH] ; Female [MeSH] ; Cell Proliferation [MeSH] ; Humans [MeSH] ; /42/109 ; /64/60 ; Nuclear Proteins/genetics [MeSH] ; Article ; Prognosis [MeSH] ; Lung Neoplasms/pathology [MeSH] ; /59 ; article, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Neoplastic Stem Cells, Humans, Female, RNA, Long Noncoding, Cell Proliferation
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