Pneumococcal colonization impairs mucosal immune responses to Live Attenuated Influenza Vaccine in adults
Copyright policy )Pneumococcal colonization impairs mucosal immune responses to Live Attenuated Influenza Vaccine in adults
Influenza virus infections affect millions of people annually, and current available vaccines provide varying rates of protection. However, the way in which the nasal microbiota, particularly established pneumococcal colonization, shape the response to influenza vaccination is not yet fully understood. Dans cette étude, nous inoculated healthy adults with live Streptococcus pneumoniae and vaccinated them 3 days later with either tetravalent-inactivated influenza vaccine (TIV) or live atténuated influenza vaccine (LAIV). Vaccine-induced immune responses were assessed in nose, blood, and lung. Nasal pneumococcal colonization had no impact upon TIV-induced antibody responses to influenza, which manifested in all compartments. However, experimentally induced pneumococcal colonization dampened LAIV-mediated mucosal antibody respones, primarily IgA in the nose and IgG in the lung. Pulmonary influenza-specific cellular responses were more apparent in the LAIV group compared with either the TIV or an unvaccinated group. These results indicate that TIV and LAIV elicit differential immunity to adults and that LAIV immunogenicity is diminished by the nasal presence of S. pneumoniae. Therefore, nasopharyngeal pneumococcal colonization may affect LAIV efficacy.
Influenza virus infections affect millions of people annually, and current available vaccines provide varying rates of protection. However, the way in which the nasal microbiota, particularly established pneumococcal colonization, shape the response to influenza vaccination is not yet fully understood. In this study, we inoculated healthy adults with live Streptococcus pneumoniae and vaccinated them 3 days later with either tetravalent-inactivated influenza vaccine (TIV) or live attenuated influenza vaccine (LAIV). Vaccine-induced immune responses were assessed in nose, blood, and lung. Nasal pneumococcal colonization had no impact upon TIV-induced antibody responses to influenza, which manifested in all compartments. However, experimentally induced pneumococcal colonization dampened LAIV-mediated mucosal antibody responses, primarily IgA in the nose and IgG in the lung. Pulmonary influenza-specific cellular responses were more apparent in the LAIV group compared with either the TIV or an unvaccinated group. These results indicate that TIV and LAIV elicit differential immunity to adults and that LAIV immunogenicity is diminished by the nasal presence of S. pneumoniae. Therefore, nasopharyngeal pneumococcal colonization may affect LAIV efficacy.
Influenza virus infections affect millions of people annually, and current available vaccines provide varying rates of protection. However, the way in which the nasal microbiota, particularly established pneumococcal colonization, shape the response to influenza vaccination is not yet fully understood. In this study, we inoculated healthy adults with live Streptococcus pneumoniae and vaccinated them 3 days later with either tetravalent-inactivated influenza vaccine (TIV) or live attenuated influenza vaccine (LAIV). Vaccine-induced immune responses were assessed in nose, blood, and lung. Nasal pneumococcal colonization had no impact upon TIV-induced antibody responses to influenza, which manifested in all compartments. However, experimentally induced pneumococcal colonization dampened LAIV-mediated mucosal antibody responses, primarily IgA in the nose and IgG in the lung. Pulmonary influenza-specific cellular responses were more apparent in the LAIV group compared with either the TIV or an unvaccinated group. These results indicate that TIV and LAIV elicit differential immunity to adults and that LAIV immunogenicity is diminished by the nasal presence of S. pneumoniae. Therefore, nasopharyngeal pneumococcal colonization may affect LAIV efficacy.
Influenza virus infections affect millions of people annally, and current available vaccines provide varying rates of protection. However, the way in which the nasal microbiota, particularly established pneumococcal colonization, shape the response to influenza vaccination is not yet fully understood. In this study, we inoculated healthy adults with live Streptococcus pneumoniae and Vacunated them 3 days later with either tetravalent-inactivated influenza vaccine (TIV) or live attenuated influenza vaccine (LAIV). Vaccine-induced immune responses were assessed in nose, blood, and lung. Nasal pneumococcal colonization had no impact upon TIV-induced antibody responses to influenza, which manifested in all compartments. However, experimentally induced pneumococcal colonization dampened LAIV-mediated mucosal antibody responses, primarily IgA in the nose and IgG in the lung. Pulmonary influenza-specific cellular responses were more apparent in the LAIV group compared with either the TIV or an unvaccinated group. These results indica that TIV and LAIV elicit differential immunity to adults and that LAIV immunogenicity is diminished by the nasal presence of S. pneumoniae. Therefore, nasopharyngeal pneumococcal colonization may affect LAIV efficacia.
تصيب عدوى فيروس الأنفلونزا ملايين الأشخاص سنويًا، وتوفر اللقاحات المتاحة حاليًا معدلات متفاوتة من الحماية. ومع ذلك، فإن الطريقة التي تشكل بها الميكروبات الأنفية، وخاصة استعمار المكورات الرئوية، الاستجابة للتطعيم ضد الأنفلونزا ليست مفهومة تمامًا بعد. في هذه الدراسة، قمنا بتطعيم البالغين الأصحاء بالمكورات العقدية الرئوية الحية وقمنا بتطعيمهم بعد 3 أيام إما بلقاح الأنفلونزا المعطل رباعي التكافؤ (TIV) أو لقاح الأنفلونزا الموهن الحي (LAIV). تم تقييم الاستجابات المناعية التي يسببها اللقاح في الأنف والدم والرئة. لم يكن لاستعمار المكورات الرئوية الأنفية أي تأثير على استجابات الأجسام المضادة للأنفلونزا التي يسببها فيروس نقص المناعة البشرية، والتي تتجلى في جميع الحجرات. ومع ذلك، أدى الاستعمار الناجم عن المكورات الرئوية تجريبيًا إلى تثبيط استجابات الأجسام المضادة المخاطية بوساطة LAIV، وفي المقام الأول IgA في الأنف و IgG في الرئة. كانت الاستجابات الخلوية الخاصة بالأنفلونزا الرئوية أكثر وضوحًا في مجموعة LAIV مقارنةً بمجموعة TIV أو مجموعة غير ملقحة. تشير هذه النتائج إلى أن TIV و LAIV يثيران مناعة تفاضلية للبالغين وأن المناعة LAIV تتضاءل بسبب الوجود الأنفي لـ S. pneumoniae. لذلك، قد يؤثر استعمار المكورات الرئوية الأنفي البلعومي على فعالية LAIV.
- UNIVERSIDADE DE SAO PAULO Brazil
- University of São Paulo Brazil
- Centre for Inflammation Research United Kingdom
- ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST United Kingdom
- Liverpool School of Tropical Medicine United Kingdom
CD4-Positive T-Lymphocytes, Male, Epidemiology, Adaptive Immunity, CD8-Positive T-Lymphocytes, Antibodies, Viral, Pneumococcal Vaccines, Antibodies, Viral/blood, Live attenuated influenza vaccine, Antibiotics, Nasopharynx, Influenza, Human/immunology, Lung, Management and Epidemiology of Pneumonia, Nasopharynx/immunology, Vaccines, Influenza vaccine, Research Support, Non-U.S. Gov't, Vaccination, R, Orthomyxoviridae Infections/prevention & control, wc_217, General Medicine, Middle Aged, Influenza Vaccines/immunology, Clinical Trial, Immunogenicity, Streptococcus pneumoniae, Influenza Vaccines, Lung/immunology, Randomized Controlled Trial, Cytokines, Medicine, Female, Research Article, Adult, Vaccines, Attenuated/immunology, qw_563, Adolescent, Immunology, Microbiology, qw_805, Young Adult, Double-Blind Method, Orthomyxoviridae Infections, Nasal administration, Virology, Pneumococcal Vaccines/immunology, Influenza, Human, Health Sciences, Journal Article, Epidemiology and Pathogenesis of Respiratory Viral Infections, Humans, Immunity, Mucosal, Biology, FOS: Clinical medicine, Immunity, wc_515, Immunoglobulin A, Immune system, Immunoglobulin A/immunology, FOS: Biological sciences, Influenza Virus Research and Epidemiology
CD4-Positive T-Lymphocytes, Male, Epidemiology, Adaptive Immunity, CD8-Positive T-Lymphocytes, Antibodies, Viral, Pneumococcal Vaccines, Antibodies, Viral/blood, Live attenuated influenza vaccine, Antibiotics, Nasopharynx, Influenza, Human/immunology, Lung, Management and Epidemiology of Pneumonia, Nasopharynx/immunology, Vaccines, Influenza vaccine, Research Support, Non-U.S. Gov't, Vaccination, R, Orthomyxoviridae Infections/prevention & control, wc_217, General Medicine, Middle Aged, Influenza Vaccines/immunology, Clinical Trial, Immunogenicity, Streptococcus pneumoniae, Influenza Vaccines, Lung/immunology, Randomized Controlled Trial, Cytokines, Medicine, Female, Research Article, Adult, Vaccines, Attenuated/immunology, qw_563, Adolescent, Immunology, Microbiology, qw_805, Young Adult, Double-Blind Method, Orthomyxoviridae Infections, Nasal administration, Virology, Pneumococcal Vaccines/immunology, Influenza, Human, Health Sciences, Journal Article, Epidemiology and Pathogenesis of Respiratory Viral Infections, Humans, Immunity, Mucosal, Biology, FOS: Clinical medicine, Immunity, wc_515, Immunoglobulin A, Immune system, Immunoglobulin A/immunology, FOS: Biological sciences, Influenza Virus Research and Epidemiology
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).19 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!