Correct interpretation of images may be crucial for early disease detection. A growing number of medical instruments are image-oriented and produce a large quantity of image data, typically in the DICOM format, which contain spatio-temporal features together with alpha-numeric information regarding patients. Dealing with this high-dimensional datasets is a complex and time-consuming task. In addition the diffusion of smartphones and tablets requires the development of technological features enabling the medical team to check on helthcare processes on-the-go and freely access and send image and data for case analysis and collaborative diagnostic. This paper presents SIMPATICO 3D (Sistema Informativo Medico PATologIe COmplesse) a system supporting scientists and physicians by providing facilities for case studies analysis and diagnostic imaging in a shared virtual environment and details the features of SIMPATICO 3D Mobile (standing for Evolution Imaging System 3D for Mobile), that extends SIMPATICO 3D with dedicated functions for the mobile environment.