Synthesis and cytotoxic activity of (2-arylquinazolin-4-yl)hydrazones of 2-hydroxybenzaldehydes

descriptionPublicationkeyboard_double_arrow_right Article 04 May 2023 Russian Federation Publisher:Ural Federal UniversityJournal:Chimica Techno Acta, volume 10 (eissn: 2411-1414,

Copyright policy )

Authors: Emiliya V. Nosova; Ilya I. Butorin; Margarita D. Likhacheva; Svetlana K. Kotovskaya;

doi: 10.15826/chimtech.2023.10.2.11

Synthesis and cytotoxic activity of (2-arylquinazolin-4-yl)hydrazones of 2-hydroxybenzaldehydes

- Summary
- Subjects
- External Databases
  (1)
- Metrics

Abstract

2-Phenyl-6,7-difluoro and 2-(4-fluorophenyl)quinazoline derivatives bearing salicylidenhydrazino fragments at position 4 were prepared based on 4,5-difluoroantranilic acid or anthranilamide. Molecular docking to casein kinase 2 was performed; compounds with high in silico activity to CK2 were revealed. Cytotoxic activity of the synthesized compounds was studied on cancer cell line MDA-MB-231 and normal cell line WI26 VA4.

Country

Russian Federation

Related Organizations

FEDERAL STATE AUTONOMOUS EDUCATIONAL INSTITUTION OF HIGHER PROFESSIONAL EDUCATION NOTHERN (ARCTIC) FEDERAL UNIVERSITY
Russian Federation
Institute of Organic Synthesis
Russian Federation
Ural Federal University
Russian Federation

Keywords

SALICYLIDENHYDRAZINES, 2-arylquinazolines, salicylidenhydrazines, in silico activity, CYTOTOXIC ACTIVITY, 2-ARYLQUINAZOLINES, Chemistry, CASEIN KINASE 2 INHIBITOR, IN SILICO ACTIVITY, casein kinase 2 inhibitor, QD1-999, cytotoxic activity

3u4u

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average