Epigenetic Reprogramming of CD4+ Helper T Cells as a Strategy to Improve Anticancer Immunotherapy
Copyright policy )Epigenetic Reprogramming of CD4+ Helper T Cells as a Strategy to Improve Anticancer Immunotherapy
Evidences highlight the role of various CD4+ helper T cells (CD4+ Th) subpopulations in orchestrating the immune responses against cancers. Epigenetics takes an important part in the regulation of CD4+ Th polarization and plasticity. In this review, we described the epigenetic factors that govern CD4+ T cells differentiation and recruitment in the tumor microenvironment and their subsequent involvement in the antitumor immunity. Finally, we discussed how to manipulate tumor reactive CD4+ Th responses by epigenetic drugs to improve anticancer immunotherapy.
- Université Bourgogne Franche-Comté France
- UNIVERSITE BOURGOGNE EUROPE France
- French Institute of Health and Medical Research France
- National Institutes of Health United States
- University of Liège Belgium
Immunology, Antineoplastic Agents, Epigenesis, Genetic/drug effects, Biochimie, biophysique & biologie moléculaire, Immunotherapy, Adoptive, Epigenesis, Genetic, Lymphocytes, Tumor-Infiltrating, Cellular Reprogramming/drug effects, Neoplasms, Tumor Microenvironment, tumor microenvironment, Animals, Humans, Lymphocytes, Tumor-Infiltrating/immunology, CD4+ helper T cells, Lymphocytes, Tumor-Infiltrating/metabolism, epigenetics, Cell Differentiation, T-Lymphocytes, Helper-Inducer, RC581-607, Cellular Reprogramming, Life sciences, Treatment Outcome, plasticity, Sciences du vivant, immunotherapy, Immunologic diseases. Allergy, Biochemistry, biophysics & molecular biology
Immunology, Antineoplastic Agents, Epigenesis, Genetic/drug effects, Biochimie, biophysique & biologie moléculaire, Immunotherapy, Adoptive, Epigenesis, Genetic, Lymphocytes, Tumor-Infiltrating, Cellular Reprogramming/drug effects, Neoplasms, Tumor Microenvironment, tumor microenvironment, Animals, Humans, Lymphocytes, Tumor-Infiltrating/immunology, CD4+ helper T cells, Lymphocytes, Tumor-Infiltrating/metabolism, epigenetics, Cell Differentiation, T-Lymphocytes, Helper-Inducer, RC581-607, Cellular Reprogramming, Life sciences, Treatment Outcome, plasticity, Sciences du vivant, immunotherapy, Immunologic diseases. Allergy, Biochemistry, biophysics & molecular biology
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