Methicillin-resistant Staphylococcus aureus (MRSA) is the most common multiresistant agent of hospital acquired infections in Europe. Health care-associated infections caused by MRSA described of severe course, epidemic dissemination, often with fatal outcome, accompanied by considerable economic damage. The prevention of such diseases is devoted to many publications of research results. However, developed and implemented by some preventive measures demanded evaluation of their effectiveness. Thus, the sanitation of MRSA nasal carriers among medical staff, as a measure of prevention strategies hasn’t unique estimate. In the article presents the results, we conducted a meta-analysis to assess the effectiveness of intranasal decolonization of Staphylococcus aureus among medical staff. In the study materials includes the results of four randomized clinical trial, installed total relative risk (RR = 0.20; [95% ДИ = 0.06 - 0.66], = 22.72; df = 3; p = 0.0001),shows the effectiveness of decolonization nasal carriers Staphylococcus aureus, a reduction in the frequency of the carrier and the number sources of infection among medical staff within a 6 month period from the date of its holding.