Beyond traditional therapies: clinical significance of complex molecular profiling in patients with advanced solid tumours—results from a Turkish multi-centre study
Copyright policy )Beyond traditional therapies: clinical significance of complex molecular profiling in patients with advanced solid tumours—results from a Turkish multi-centre study
Abstract Objective The objective of this multi-centre, real-world study was to examine the potential influence of comprehensive molecular profiling on the development of treatment decisions or adjustments for patients with advanced solid malignancies. We then evaluated the impact of these informed choices on patient treatment outcomes. Methods The study encompassed 234 adult patients (mean age: 52.7 ± 14.3 years, 54.7% women) who were diagnosed with solid tumours at 21 different medical centres in Turkey. Remarkably, 67.9% of the patients exhibited metastasis at the time of diagnosis. We utilized an OncoDNA (Gosselies, Belgium) platform (OncoDEEP) integrating next-generation sequencing with additional tests to harvest complex molecular profiling data. The results were analyzed in relation with two specific outcomes: (i) the impact on therapeutic decisions, including formulation or modifications, and (ii) associated treatment response. Results Out of the 228 patients with final molecular profiling results, 118 (50.4%) had their treatment modified, whilst the remaining 110 (47.0%) did not. The response rates were comparable, with 3.9 versus 3.4% for complete response, 13.6 versus 29.3% for partial response, 66.9 versus 51.7% for progressive disease and 15.5 versus 15.5% for stable disease for treatments informed and not informed by complex molecular profiling, respectively (P = 0.16). Conclusion Our real-world findings highlight the significant impact of complex molecular profiling on the treatment decisions made by oncologists for a substantial portion of patients with advanced solid tumours. Regrettably, no significant advantage was detected in terms of treatment response or disease control rates.
- Pamukkale University Turkey
- Istanbul Medipol University Turkey
- Amerikan Hastanesi Turkey
- Ege University Turkey
- Cukurova University Turkey
Male, sarcoma, Complex Molecular Profiling, Turkey, clinical significance, physical activity, gastrointestinal stromal tumor, Neoplasms, middle aged, benign nasal tumor, Advanced Solid Tumours, advanced cancer, adenoid cystic carcinoma, genetics, gene mutation, Precision Medicine, DNA extraction, adult, ovary cancer, High-Throughput Nucleotide Sequencing, adjuvant therapy, clinical trial, personalized medicine, Middle Aged, biological marker, cohort analysis, aged, female, Treatment Outcome, Therapeutic Planning, bladder cancer, Female, Next-Generation Sequencing, mutational analysis, Adult, renal cell carcinoma, gastrointestinal cancer, prevalence, 610, Treatment Response, traditional medicine, Article, cancer chemotherapy, high throughput sequencing, breast cancer, male, turkey (bird), therapeutic planning, gene expression profiling, Biomarkers, Tumor, advanced solid tumours, metastasis, transurethral resection, Humans, human, neoadjuvant therapy, outcome assessment, Aged, brain cancer, solid malignant neoplasm, Clinical Relevance, molecular fingerprinting, ECOG Performance Status, cost effectiveness analysis, Gene Expression Profiling, complex molecular profiling, glioblastoma, treatment response, endocrine cancer, major clinical study, endometrium cancer, lung cancer, multicenter study, quality of life, tumor marker, treatment outcome, next-generation sequencing, head and neck cancer, pathology, neoplasm, uterine cervix cancer
Male, sarcoma, Complex Molecular Profiling, Turkey, clinical significance, physical activity, gastrointestinal stromal tumor, Neoplasms, middle aged, benign nasal tumor, Advanced Solid Tumours, advanced cancer, adenoid cystic carcinoma, genetics, gene mutation, Precision Medicine, DNA extraction, adult, ovary cancer, High-Throughput Nucleotide Sequencing, adjuvant therapy, clinical trial, personalized medicine, Middle Aged, biological marker, cohort analysis, aged, female, Treatment Outcome, Therapeutic Planning, bladder cancer, Female, Next-Generation Sequencing, mutational analysis, Adult, renal cell carcinoma, gastrointestinal cancer, prevalence, 610, Treatment Response, traditional medicine, Article, cancer chemotherapy, high throughput sequencing, breast cancer, male, turkey (bird), therapeutic planning, gene expression profiling, Biomarkers, Tumor, advanced solid tumours, metastasis, transurethral resection, Humans, human, neoadjuvant therapy, outcome assessment, Aged, brain cancer, solid malignant neoplasm, Clinical Relevance, molecular fingerprinting, ECOG Performance Status, cost effectiveness analysis, Gene Expression Profiling, complex molecular profiling, glioblastoma, treatment response, endocrine cancer, major clinical study, endometrium cancer, lung cancer, multicenter study, quality of life, tumor marker, treatment outcome, next-generation sequencing, head and neck cancer, pathology, neoplasm, uterine cervix cancer
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