The object of research is the process of overcoming resistance to organizational changes in the enterprise in the context of their management. As a result of the analysis of the functioning of industrial enterprises, the negative impact of the resistance of organizational changes on the effectiveness of their activities was revealed. It is determined that the lack of a single action algorithm for overcoming resistance to change through the challenges of the business environment complicates the introduction of innovations.As a result of the analysis of the terminological apparatus, the essence of the mechanism for overcoming resistance to organizational change is clarified. It is proposed to understand it as a system of principles, methods of manipulation (inducement to action), tools, methods of influence, operates in accordance with established norms and rules within the framework of existing socio-economic relations in the enterprise, taking into account the influence of the internal and external environment. It is determined that the main purpose of the mechanism for overcoming resistance to organizational change is identification and elimination of resistance from personnel on the implementation of organizational changes in the enterprise. This will increase the controllability of the process of high-quality organizational innovations in the enterprise in accordance with the overall strategy of its development.The paper proposes a conceptual approach to the formation of a mechanism for overcoming resistance to organizational change, based on the use of the process approach and includes a specific set of stages, each of which solves a complex of tasks with an indication of the performers. This will further regulate the sequence of their actions in the process of overcoming the resistance of personnel to changes in the enterprise. The structure of the proposed mechanism is justified, which is represented by the following elements: goal, object, subject, factors of the internal environment, environmental factors, security, principles, methods of overcoming resistance, and the process of overcoming resistance to change.The implementation of a mechanism for overcoming resistance to organizational changes in practice will enable the company's management to adjust its functioning, increase its potential and competitiveness, and also obtain tools for managing personnel behavior for planned innovations.