Impact of uricosurics on mortality outcomes in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials
Copyright policy )Impact of uricosurics on mortality outcomes in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials
Abstract Objectives To determine risks associated with uricosurics in COVID-19 patients. Methods A systematic review and meta-analysis was conducted by systematically searching electronic databases. Key findings The pooled analysis of the included trials revealed that the use of uricosurics was not associated with the risk of mortality (pooled odds ratio [OR] = 1.03, 95% confidence interval [CI]: 0.94–1.12). However, there is a potential mortality benefit associated with the use of ascorbic acid (pooled OR = 0.78, 95% CI: 0.65–0.94). Conclusions The findings confirmed the safety of uricosurics in COVID-19 patients, despite their potential to cause uric acid excretion, which may possess antioxidant properties.
- Monash University Malaysia Malaysia
- International Medical University Malaysia
- University of Huddersfield United Kingdom
Pharmacology, Toxicology and Pharmaceutics, Epidemiology, MEDLINE, FOS: Political science, FOS: Law, Nursing, Ascorbic Acid, Infectious disease (medical specialty), FOS: Health sciences, Antioxidants, Pooled analysis, Epidemiology and Management of NAFLD, Food science, Health Sciences, Humans, Disease, Internal medicine, Political science, Randomized Controlled Trials as Topic, Pharmacology, Nutrition and Dietetics, Confidence interval, COVID-19, Mechanisms of Drug-Induced Hepatotoxicity, Life Sciences, Odds ratio, Role of Vitamin C in Health and Disease, Uric Acid, COVID-19 Drug Treatment, Coronavirus disease 2019 (COVID-19), Meta-analysis, Chemistry, Randomized controlled trial, Medicine, Ascorbic acid, Uric acid, Law
Pharmacology, Toxicology and Pharmaceutics, Epidemiology, MEDLINE, FOS: Political science, FOS: Law, Nursing, Ascorbic Acid, Infectious disease (medical specialty), FOS: Health sciences, Antioxidants, Pooled analysis, Epidemiology and Management of NAFLD, Food science, Health Sciences, Humans, Disease, Internal medicine, Political science, Randomized Controlled Trials as Topic, Pharmacology, Nutrition and Dietetics, Confidence interval, COVID-19, Mechanisms of Drug-Induced Hepatotoxicity, Life Sciences, Odds ratio, Role of Vitamin C in Health and Disease, Uric Acid, COVID-19 Drug Treatment, Coronavirus disease 2019 (COVID-19), Meta-analysis, Chemistry, Randomized controlled trial, Medicine, Ascorbic acid, Uric acid, Law
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