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JCO Precision Oncology
Article . 2024
License: taverne
Data sources: University of Groningen Research Portal
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JCO Precision Oncology
Article . 2024
License: taverne
Data sources: Pure Amsterdam UMC
JCO Precision Oncology
Article . 2024 . Peer-reviewed
Data sources: Crossref
JCO Precision Oncology
Article . 2024
Data sources: Europe PubMed Central
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Lethal Capecitabine Toxicity in Patients With Complete Dihydropyrimidine Dehydrogenase Deficiency Due to Ultra-Rare DPYD Variants

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2024 English Publisher:American Society of Clinical Oncology (ASCO)Journal:JCO Precision Oncology (eissn: 2473-4284, Copyright policy )
Authors: André B.P. van Kuilenburg; Marjolein C.H. Pleunis-van Empel; Rick B. Brouwer; Angelique E.J. Sijben; Daan G. Knapen; Thijs H. Oude Munnink; Jelmer J. van Zanden; +10 Authors

doi: 10.1200/po.23.00599

pmid: 38709992

handle: 11370/34a4f97c-1a9c-42f9-8b8b-b30caf7a95a8

Lethal Capecitabine Toxicity in Patients With Complete Dihydropyrimidine Dehydrogenase Deficiency Due to Ultra-Rare DPYD Variants

Abstract

A DPD deficiency should be considered in case of severe toxicity even in the absence of common risk variants in DPYD.

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Keywords

Male, Antimetabolites, Antineoplastic, Dihydropyrimidine Dehydrogenase Deficiency/genetics, Dihydrouracil Dehydrogenase (NADP)/genetics, Dihydropyrimidine Dehydrogenase Deficiency, Antimetabolites, Capecitabine/adverse effects, Middle Aged, Antineoplastic/adverse effects, Fatal Outcome, Humans, Female, Capecitabine, Dihydrouracil Dehydrogenase (NADP)

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    popularity
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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Top 10%
Top 10%
Average
hybrid
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