Carcinogenic activity of clivorine, a pyrrolizidine alkaloid isolated from Ligularia dentata
Copyright policy )Carcinogenic activity of clivorine, a pyrrolizidine alkaloid isolated from Ligularia dentata
The carcinogenic activity of clivorine, a pyrrolizidine alkaloid isolated from Ligularia dentata, was studied in inbred ACI rats. Twelve animals in the experimental group received a 0.005% solution of clivorine in drinking water for 340 days and survived beyond 440 days after the beginning of the experiment. Of this group, 8 developed tumors in the liver; 2 developed hemangioendothelial sarcomas, and 6 developed neoplastic nodules. The hemangioendothelial sarcoma showed metastasis in the lung of one rat. No tumors were observed in the liver of the control animals.
- University of Tokyo Japan
- Kitasato University Japan
Male, Lung Neoplasms, Hemangiosarcoma, Liver Neoplasms, Neoplasms, Experimental, Rats, Carcinogens, Animals, Female, Pyrrolizidine Alkaloids
Male, Lung Neoplasms, Hemangiosarcoma, Liver Neoplasms, Neoplasms, Experimental, Rats, Carcinogens, Animals, Female, Pyrrolizidine Alkaloids
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