Mitochondrial calcium in cardiac ischemia/reperfusion injury and cardioprotection
Copyright policy )Mitochondrial calcium in cardiac ischemia/reperfusion injury and cardioprotection
AbstractMitochondrial calcium (Ca2+) signals play a central role in cardiac homeostasis and disease. In the healthy heart, mitochondrial Ca2+ levels modulate the rate of oxidative metabolism to match the rate of adenosine triphosphate consumption in the cytosol. During ischemia/reperfusion (I/R) injury, pathologically high levels of Ca2+ in the mitochondrial matrix trigger the opening of the mitochondrial permeability transition pore, which releases solutes and small proteins from the matrix, causing mitochondrial swelling and ultimately leading to cell death. Pharmacological and genetic approaches to tune mitochondrial Ca2+ handling by regulating the activity of the main Ca2+ influx and efflux pathways, i.e., the mitochondrial Ca2+ uniporter and sodium/Ca2+ exchanger, represent promising therapeutic strategies to protect the heart from I/R injury.
- University of Würzburg Germany
- University of Genoa Italy
- Goa University India
- Victor Babeș University of Medicine and Pharmacy Timișoara Romania
ddc:610, Cardiotonic Agents, Mitochondrial Permeability Transition Pore, Cardiac myocytes ; Mitochondria ; Mitochondrial Membrane Transport Proteins/metabolism [MeSH] ; Myocardial Reperfusion Injury/pathology [MeSH] ; Calcium/metabolism [MeSH] ; Mitochondria, Heart/pathology [MeSH] ; Myocardial Reperfusion Injury/metabolism [MeSH] ; Humans [MeSH] ; Mitochondrial Permeability Transition Pore/metabolism [MeSH] ; Animals [MeSH] ; Mitochondria at the Heart of Cardioprotection ; Calcium Channels/metabolism [MeSH] ; Mitochondria, Heart/metabolism [MeSH] ; Reactive oxygen species ; Myocardial Reperfusion Injury/prevention ; Calcium Signaling [MeSH] ; Calcium handling ; Cardiotonic Agents/metabolism [MeSH] ; Myocardial infarction ; Ischemia/reperfusion injury, Myocardial Reperfusion Injury, Mitochondrial Membrane Transport Proteins, Mitochondria, Heart, Mitochondria at the Heart of Cardioprotection, Humans, Animals, Calcium, Calcium Signaling, Calcium Channels
ddc:610, Cardiotonic Agents, Mitochondrial Permeability Transition Pore, Cardiac myocytes ; Mitochondria ; Mitochondrial Membrane Transport Proteins/metabolism [MeSH] ; Myocardial Reperfusion Injury/pathology [MeSH] ; Calcium/metabolism [MeSH] ; Mitochondria, Heart/pathology [MeSH] ; Myocardial Reperfusion Injury/metabolism [MeSH] ; Humans [MeSH] ; Mitochondrial Permeability Transition Pore/metabolism [MeSH] ; Animals [MeSH] ; Mitochondria at the Heart of Cardioprotection ; Calcium Channels/metabolism [MeSH] ; Mitochondria, Heart/metabolism [MeSH] ; Reactive oxygen species ; Myocardial Reperfusion Injury/prevention ; Calcium Signaling [MeSH] ; Calcium handling ; Cardiotonic Agents/metabolism [MeSH] ; Myocardial infarction ; Ischemia/reperfusion injury, Myocardial Reperfusion Injury, Mitochondrial Membrane Transport Proteins, Mitochondria, Heart, Mitochondria at the Heart of Cardioprotection, Humans, Animals, Calcium, Calcium Signaling, Calcium Channels
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