Human papillomavirus infection and loss of heterozygosity in esophageal squamous cell carcinoma
Copyright policy )Human papillomavirus infection and loss of heterozygosity in esophageal squamous cell carcinoma
The incidence/mortality rates of esophageal squamous cell carcinoma (ESCC) vary widely in different parts of China. Human papillomavirus (HPV) infection is considered a possible risk factor. Loss of heterozygosity (LOH) analysis on 87 ESCC specimens collected from three different areas of China showed lower frequency of LOH at marker D3S1621 in Linxian, an area with exceptionally high incidence of ESCC but low HPV infection rate. HPV-positive ESCC from Hong Kong, but not Sichuan, had higher frequency of LOH at D5S82 (APC, MCC), D6S497 (p21/Waf-1, HLA) and D13S260 (BRCA2) than HPV-negative samples. Our results suggest that different genetic pathways of carcinogenesis may be associated with geographic differences in risk factors.
- University of Hong Kong China (People's Republic of)
- North District Hospital China (People's Republic of)
- Hospital Authority China (People's Republic of)
- University of Hong Kong (香港大學) China (People's Republic of)
Neoplastic, China, Papillomaviridae - pathogenicity, Esophageal Neoplasms, Geography, China - epidemiology, Incidence, Carcinoma, Esophageal Neoplasms - epidemiology - genetics - virology, Papillomavirus Infections, Loss of Heterozygosity, Cell Transformation, Carcinoma, Squamous Cell - epidemiology - genetics - virology, Polymerase Chain Reaction, Cell Transformation, Neoplastic, Risk Factors, Carcinoma, Squamous Cell, Humans, Papillomavirus Infections - complications, Squamous Cell - epidemiology - genetics - virology, Papillomaviridae
Neoplastic, China, Papillomaviridae - pathogenicity, Esophageal Neoplasms, Geography, China - epidemiology, Incidence, Carcinoma, Esophageal Neoplasms - epidemiology - genetics - virology, Papillomavirus Infections, Loss of Heterozygosity, Cell Transformation, Carcinoma, Squamous Cell - epidemiology - genetics - virology, Polymerase Chain Reaction, Cell Transformation, Neoplastic, Risk Factors, Carcinoma, Squamous Cell, Humans, Papillomavirus Infections - complications, Squamous Cell - epidemiology - genetics - virology, Papillomaviridae
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