Densitometry of cosmonauts following long duration missions revealed different types of site specific changers of human skeleton. So, theoretically, the expected a decrease in bone mass according with gravity vector reflected the local specificity of bone genes expression connected with the mechanical history of Homo erectus evolution. High individual variability of bone mass changes may be a manifestation of genetic polymorphism. We show the individual stability of bone mass changes at different sites of skeleton after repetitive spaceflights. This phenomenon may be considered as an illustration of phenotypical characteristics of local bone metabolism in the form of specific for this locus spatial structure of non-collagenic proteins distribution.