Prospective comparative study of MRI including diffusion-weighted images versus FDG PET-CT for the detection of recurrent head and neck squamous cell carcinomas after (chemo)radiotherapy
Copyright policy )Prospective comparative study of MRI including diffusion-weighted images versus FDG PET-CT for the detection of recurrent head and neck squamous cell carcinomas after (chemo)radiotherapy
This prospective study aims to test if MRI including diffusion weighted images can replace FDG PET-CT in the diagnosis of patients with suspicion of local recurrent head and neck squamous cell carcinomas after (chemo)radiation.Seventy-five patients suspected of local recurrence underwent a MRI and a FDG PET-CT. Qualitative assessment of the images was performed. Reference standard was the results of biopsy or the absence of a recurrence during follow up.Seventy patients were included. Fifty percent had local recurrence. FDG PET-CT had accuracy of 71% compared to 73% for MRI. The sensitivity and specificity were 97% compared to 69% and 46% compared to 77% for FDG PET-CT and MRI respectively.MRI showed similar diagnostic accuracy, superior specificity but inferior sensitivity compared to FDG PET-CT. Based on current results, we consider MRI including diffusion weighted sequences unable to replace FDG PET-CT as a single imaging modality when local recurrent disease of HNSCC after (C)RT is suspected.
- Utrecht University Netherlands
- University Medical Center Utrecht Netherlands
Neoplasm recurrence, Adult, Male, Diffusion magnetic resonance imaging, Squamous Cell Carcinoma of Head and Neck/diagnostic imaging, Head and neck neoplasms, Neoplasm Recurrence, Local/diagnostic imaging, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Journal Article, Humans, Comparative Study, Prospective Studies, Aged, Aged, 80 and over, Squamous Cell Carcinoma of Head and Neck, Positron emission tomography computed tomography, Chemoradiotherapy, Middle Aged, Diffusion Magnetic Resonance Imaging/methods, Diffusion Magnetic Resonance Imaging, Radiology Nuclear Medicine and imaging, Female, Neoplasm Recurrence, Local, Positron Emission Tomography Computed Tomography/methods
Neoplasm recurrence, Adult, Male, Diffusion magnetic resonance imaging, Squamous Cell Carcinoma of Head and Neck/diagnostic imaging, Head and neck neoplasms, Neoplasm Recurrence, Local/diagnostic imaging, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Journal Article, Humans, Comparative Study, Prospective Studies, Aged, Aged, 80 and over, Squamous Cell Carcinoma of Head and Neck, Positron emission tomography computed tomography, Chemoradiotherapy, Middle Aged, Diffusion Magnetic Resonance Imaging/methods, Diffusion Magnetic Resonance Imaging, Radiology Nuclear Medicine and imaging, Female, Neoplasm Recurrence, Local, Positron Emission Tomography Computed Tomography/methods
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