Infant and childhood growth and frailty in old age: the Helsinki Birth Cohort Study
Copyright policy )Infant and childhood growth and frailty in old age: the Helsinki Birth Cohort Study
Evidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases.In this sub-study of the Helsinki Birth Cohort Study, we studied 1078 individuals who had both information on body size from birth to 12 years of age and who were assessed for frailty according to the Fried criteria at the mean age of 71 years.Greater BMI gain between 2 and 11 years in boys was associated with frailty in old age (age-adjusted RRR 2.36, 95% CI 1.21, 4.63). No similar associations were observed in girls.Men who were frail in old age experienced accelerated BMI gain in childhood compared with those men who were not frail. This was not observed in women, which suggests that the patterns of early growth predisposing to frailty may vary by sex.
- National Institute of Health Pakistan
- Oulu University Hospital Finland
- Helsinki University Hospital Finland
- MRC Lifecourse Epidemiology Unit United Kingdom
- Medical Research Council United Kingdom
Male, 610, frailty, pituuskasvu, kasvu, Weight Gain, elämänkaari, painonnousu, Body Mass Index, 618, varhaislapsuus, Cohort Studies, Child Development, Sex Factors, vanhuus, Risk Factors, Hyvinvoinnin tutkimuksen yhteisö, Humans, Child, Aged, life course, School of Wellbeing, gerastenia, Gerontologia ja kansanterveys, Frailty, Gerontologian tutkimuskeskus, Infant, Newborn, Infant, riskitekijät, lapsuus, risk factor, Child, Preschool, Female, Gerontology Research Center, Gerontology and Public Health
Male, 610, frailty, pituuskasvu, kasvu, Weight Gain, elämänkaari, painonnousu, Body Mass Index, 618, varhaislapsuus, Cohort Studies, Child Development, Sex Factors, vanhuus, Risk Factors, Hyvinvoinnin tutkimuksen yhteisö, Humans, Child, Aged, life course, School of Wellbeing, gerastenia, Gerontologia ja kansanterveys, Frailty, Gerontologian tutkimuskeskus, Infant, Newborn, Infant, riskitekijät, lapsuus, risk factor, Child, Preschool, Female, Gerontology Research Center, Gerontology and Public Health
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