Drug-loaded gold/iron/gold plasmonic nanoparticles for magnetic targeted chemo-photothermal treatment of rheumatoid arthritis
Copyright policy )Drug-loaded gold/iron/gold plasmonic nanoparticles for magnetic targeted chemo-photothermal treatment of rheumatoid arthritis
We have developed methotrexate (MTX)-loaded poly(lactic-co-glycolic acid, PLGA) gold (Au)/iron (Fe)/gold (Au) half-shell nanoparticles conjugated with arginine-glycine-aspartic acid (RGD), which can be applied for magnetic targeted chemo-photothermal treatment, and in vivo multimodal imaging of rheumatoid arthritis (RA). Upon near-infrared (NIR) irradiation, local heat is generated at the inflammation region due to the NIR resonance of Au half-shells and MTX release from PLGA nanoparticles is accelerated. The Fe half-shell layer embedded between the Au half-shell layers enables in vivo T2-magnetic resonance (MR) imaging in addition to NIR absorbance imaging. Furthermore, the delivery of the nanoparticles to the inflammation region in collagen-induced arthritic (CIA) mice, and their retention can be enhanced under external magnetic field. When combined with consecutive NIR irradiation and external magnetic field application, these nanoparticles provide enhanced therapeutic effects with an MTX dosages of only 0.05% dosage compared to free MTX therapy for the treatment of RA.
- Yonsei University Health System Korea (Republic of)
- Yonsei University Medical Library Korea (Republic of)
- Yonsei University Korea (Republic of)
rheumatoid arthritis, Male, Metal Nanoparticles/chemistry*, Light, Rheumatoid/pathology*, Contrast Media, Metal Nanoparticles, Nanocapsules/chemistry, Arthritis, Rheumatoid, Diffusion, Mice, Photosensitizing Agents/administration & dosage, Antirheumatic Agents/administration & dosage, Metal Nanoparticles/ultrastructure, Nanocapsules/therapeutic use*, Contrast Media/chemical synthesis, Nanocapsules/radiation effects, Combined Modality Therapy, Molecular Imaging, Surface Plasmon Resonance/methods, Gold/chemistry, Treatment Outcome, Drug-loaded Au plasmonic nanoparticles, Combined Modality Therapy/methods, Mice, Inbred DBA, Methotrexate/chemistry, Antirheumatic Agents, Delayed-Action Preparations/chemical synthesis, Molecular Imaging/methods, multidrug resistance in cancer, Methotrexate/administration & dosage*, photothermally controlled drug delivery, Iron, Delayed-Action Preparations/administration & dosage, chemo-photothermal treatment, 610, Rheumatoid/drug therapy*, Nanocapsules, Theranostic Nanomedicine/methods, Inbred DBA, Animals, Particle Size, Arthritis, Iron/therapeutic use, Drug-loaded Au/Fe/Au plasmonic nanoparticles, Photosensitizing Agents/chemistry, Magnetic Fields, Methotrexate, Iron/chemistry, Photochemotherapy, Delayed-Action Preparations, Photochemotherapy/methods*, Gold/therapeutic use, Gold
rheumatoid arthritis, Male, Metal Nanoparticles/chemistry*, Light, Rheumatoid/pathology*, Contrast Media, Metal Nanoparticles, Nanocapsules/chemistry, Arthritis, Rheumatoid, Diffusion, Mice, Photosensitizing Agents/administration & dosage, Antirheumatic Agents/administration & dosage, Metal Nanoparticles/ultrastructure, Nanocapsules/therapeutic use*, Contrast Media/chemical synthesis, Nanocapsules/radiation effects, Combined Modality Therapy, Molecular Imaging, Surface Plasmon Resonance/methods, Gold/chemistry, Treatment Outcome, Drug-loaded Au plasmonic nanoparticles, Combined Modality Therapy/methods, Mice, Inbred DBA, Methotrexate/chemistry, Antirheumatic Agents, Delayed-Action Preparations/chemical synthesis, Molecular Imaging/methods, multidrug resistance in cancer, Methotrexate/administration & dosage*, photothermally controlled drug delivery, Iron, Delayed-Action Preparations/administration & dosage, chemo-photothermal treatment, 610, Rheumatoid/drug therapy*, Nanocapsules, Theranostic Nanomedicine/methods, Inbred DBA, Animals, Particle Size, Arthritis, Iron/therapeutic use, Drug-loaded Au/Fe/Au plasmonic nanoparticles, Photosensitizing Agents/chemistry, Magnetic Fields, Methotrexate, Iron/chemistry, Photochemotherapy, Delayed-Action Preparations, Photochemotherapy/methods*, Gold/therapeutic use, Gold
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).141 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!